Maternal glucocorticoids and prenatal programming of hypertension

American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
Lori L Woods

Abstract

Maternal glucocorticoids have been postulated to play an important role in prenatal programming for adult hypertension in the offspring. However, we have shown previously that offspring hypertension caused by maternal dexamethasone subcutaneous administration at 100 microg x kg(-1) x day(-1) can be accounted for by the corresponding reduction in food intake that these mothers experience. The present studies were designed to determine whether there is a lower dose of dexamethasone that does not reduce maternal food intake yet still causes hypertension in the adult offspring. Pregnant rats were treated with subcutaneous dexamethasone at 50 (D50) or 25 (D25) microg x kg(-1) x day(-1) on days 15-20 of pregnancy. An additional group was untreated or received vehicle injections (control). D25 and D50 dams reduced their food intake by 17% during and after treatment and gained 31% less weight than control over the course of gestation. In adulthood ( approximately 21 wk), chronically instrumented male offspring of D50 and D25 had normal blood pressures (D50: 131 +/- 2 mmHg and D25: 127 +/- 3 mmHg vs. 127 +/- 2 mmHg in control). Qualitatively similar results were found in female offspring. Thus neither dexamethasone per se at these doses...Continue Reading

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Citations

Sep 21, 2007·The New England Journal of Medicine·Caroline A CrowtherUNKNOWN ACTORDS Study Group
Nov 6, 2008·Clinical and Experimental Pharmacology & Physiology·Wenqiang LiaoXiaohui Li
Jun 15, 2010·American Journal of Physiology. Heart and Circulatory Physiology·Hossam A ShaltoutDavid B Averill
Mar 17, 2012·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Ganga GokulakrishnanMarta L Fiorotto
May 16, 2008·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·K A BrennanD M Olson
Nov 28, 2008·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Lijun TangJames C Rose
Jan 16, 2009·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Robert D RoghairFred S Lamb
Jan 15, 2010·American Journal of Physiology. Renal Physiology·Stephen A ContagJames C Rose
Feb 7, 2008·The Journal of Endocrinology·David O'ReganMegan C Holmes
Jun 10, 2011·Birth Defects Research. Part A, Clinical and Molecular Teratology·Curtis E GraceJohn M Rogers
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Aug 7, 2017·Current Hypertension Reports·Andrew C TiuVan Anthony M Villar
Mar 29, 2007·Reproduction, Fertility, and Development·Michael E SymondsHelen Budge

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