Maternal hemodynamics at 11-13 weeks' gestation in gestational diabetes mellitus

Fetal Diagnosis and Therapy
Asma KhalilKypros H Nicolaides

Abstract

Women who develop gestational diabetes mellitus (GDM) are at increased risk of type 2 diabetes and subsequent cardiovascular mortality and morbidity. Individuals with cardiovascular disorders have increased central aortic systolic blood pressure (SBP(Ao)) and arterial stiffness. The hypothesis of this study is that increased SBP(Ao) and arterial stiffness are apparent before the development of GDM. In this screening study, SBP(Ao), pulse wave velocity (PWV) and augmentation index (AIx) were measured in women with singleton pregnancies attending for routine antenatal care at 11-13 weeks' gestation. We compared SBP(Ao), PWV and AIx, expressed as multiples of the median (MoM), after adjustment for maternal characteristics affecting these measurements, in women who subsequently developed GDM (n = 105) with the values in non-GDM controls (n = 6,736). In the GDM group, compared to non-GDM controls, there was an increase in PWV [1.04 MoM, interquartile range (IQR) 0.93-1.15 vs. 1.00 MoM, IQR 0.90-1.12; p = 0.013] and SBP(Ao) (1.03 MoM, IQR 0.98-1.14 vs. 1.00 MoM, IQR 0.94-1.08; p < 0.0001) but no significant difference in the AIx (1.02 MoM, IQR 0.89-1.22 vs. 1.00 MoM, IQR 0.87-1.17; p = 0.118). Women who develop GDM have increased SBP...Continue Reading

Citations

Jan 23, 2016·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·Clare O'ConnorMáireád M Kennelly
May 15, 2012·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·A KhalilK H Nicolaides
May 9, 2014·Prenatal Diagnosis·Andrew N Sharp, Zarko Alfirevic
May 29, 2016·European Journal of Obstetrics, Gynecology, and Reproductive Biology·M A Kennelly, F M McAuliffe
Aug 23, 2019·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·A KhalilZ Alfirevic
Jul 2, 2017·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·F L FooUNKNOWN International Working Group on Maternal Hemodynamics
Jan 31, 2017·Vascular Medicine·Priyanka GargAlka Kriplani
Oct 27, 2021·Archives of Gynecology and Obstetrics·Federico MecacciHerbert Valensise

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Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology
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