Maternal high-fat diet consumption enhances offspring susceptibility to DSS-induced colitis in mice

Obesity
Shima BibiMei-Jun Zhu

Abstract

Maternal high-fat diet (HFD) may alter the offspring intestinal immune system, thereby enhancing susceptibility toward inflammatory bowel disease. The objective of the current study was to investigate the impact of maternal HFD on offspring intestinal health using a mouse model of dextran sulfate sodium (DSS)-induced colitis. Dams were provided with either HFD (60%) or control diet. After weaning, female offspring from both groups were kept on 45% HFD. At 14 weeks of age, offspring were subjected to 2.5% DSS in drinking water for 5 days, followed by 5 days of recovery. Offspring from maternal HFD had higher body weight gain before DSS induction and had higher liver and fat weights with increased adipocyte size at necropsy. When subjected to DSS treatment, HFD offspring had accelerated body weight loss and exaggerated disease activity index. HFD offspring had an elevated histopathological score and interleukin (IL)-1β, IL-6, and IL-17 expression with upregulated NF-κB signaling. Maternal HFD resulted in enhanced neutrophil infiltration associated with elevated expression of monocyte chemoattractant protein-1. Furthermore, maternal HFD suppressed AMP-activated protein kinase activity and decreased sirtuin 1 and p53 protein conten...Continue Reading

References

Feb 26, 2005·American Journal of Physiology. Gastrointestinal and Liver Physiology·Kevan JacobsonSheila M Innis
May 4, 2005·Molecular Cell·Russell G JonesCraig B Thompson
Sep 4, 2007·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·M NabulsiG E-H Fuleihan
Dec 4, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Duygu SagJill Suttles
Aug 6, 2009·The Journal of Biological Chemistry·Michael ScharlDeclan F McCole
Nov 26, 2009·Journal of Pediatric Gastroenterology and Nutrition·Hoda M MalatyGeorge D Ferry
Jun 22, 2010·Reproduction : the Official Journal of the Society for the Study of Fertility·Amanda J Drake, Rebecca M Reynolds
Nov 30, 2011·Methods in Molecular Biology·Chao-Yung Wang, James K Liao
Jan 19, 2012·JAMA : the Journal of the American Medical Association·Katherine M FlegalCynthia L Ogden
Aug 22, 2013·Molecular Nutrition & Food Research·Hui WangMei-Jun Zhu
Mar 13, 2014·Frontiers in Cellular and Infection Microbiology·Kalliopi K GkouskouAristides G Eliopoulos
Apr 30, 2014·The Journal of Nutritional Biochemistry·Yansong XueMei-Jun Zhu
Jun 18, 2014·Clinical Obstetrics and Gynecology·Christine B WilliamsSheila Gahagan
Mar 4, 2015·Nature Reviews. Gastroenterology & Hepatology·Ashwin N Ananthakrishnan
Aug 6, 2015·Journal of Leukocyte Biology·François A SimardPatrick P McDonald
Nov 20, 2016·The Journal of Nutritional Biochemistry·Yifei KangMei-Jun Zhu

❮ Previous
Next ❯

Citations

Sep 29, 2018·Nature Reviews. Gastroenterology & Hepatology·Niv ZmoraEran Elinav
Aug 7, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Zhe WangMin Chang
Sep 5, 2019·Journal of Leukocyte Biology·Suhas SureshchandraIlhem Messaoudi
Jul 23, 2020·Nature Metabolism·Ziad Al NabhaniGérard Eberl
Feb 20, 2021·Frontiers in Immunology·Abigail R BassonAlex Rodriguez-Palacios
Apr 30, 2021·Frontiers in Immunology·Suhas SureshchandraIlhem Messaoudi

❮ Previous
Next ❯

Methods Mentioned

BETA
Infrared Imaging
PCR

Software Mentioned

Image [UNK] Lite
Image J

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.