Maternal high-fat diet impairs cardiac function in offspring of diabetic pregnancy through metabolic stress and mitochondrial dysfunction

American Journal of Physiology. Heart and Circulatory Physiology
Kennedy S MdakiMichelle L Baack

Abstract

Offspring of diabetic pregnancies are at risk of cardiovascular disease at birth and throughout life, purportedly through fuel-mediated influences on the developing heart. Preventative measures focus on glycemic control, but the contribution of additional offenders, including lipids, is not understood. Cellular bioenergetics can be influenced by both diabetes and hyperlipidemia and play a pivotal role in the pathophysiology of adult cardiovascular disease. This study investigated whether a maternal high-fat diet, independently or additively with diabetes, could impair fuel metabolism, mitochondrial function, and cardiac physiology in the developing offspring's heart. Sprague-Dawley rats fed a control or high-fat diet were administered placebo or streptozotocin to induce diabetes during pregnancy and then delivered offspring from four groups: control, diabetes exposed, diet exposed, and combination exposed. Cardiac function, cellular bioenergetics (mitochondrial stress test, glycolytic stress test, and palmitate oxidation assay), lipid peroxidation, mitochondrial histology, and copy number were determined. Diabetes-exposed offspring had impaired glycolytic and respiratory capacity and a reduced proton leak. High-fat diet-exposed...Continue Reading

References

Dec 1, 1991·The American Journal of Physiology·G D LopaschukD R Marsh
Jan 1, 1991·The Journal of Pediatrics·H S WeberC S Kleinman
Mar 30, 1989·Nature·D J Barker
Dec 1, 1980·Diabetes·N Freinkel
Aug 4, 1995·Biochemical and Biophysical Research Communications·T D O'Connell, R U Simpson
Aug 22, 2001·American Journal of Physiology. Heart and Circulatory Physiology·H Van RemmenA Richardson
Mar 1, 2005·Diabetes Care·Dana DabeleaUNKNOWN Kaiser Permanente of Colorado GDM Screening Program
Mar 22, 2005·Biochemical Society Symposium·Martin D BrandKarim S Echtay
Jul 1, 2005·Physiological Reviews·William C StanleyGary D Lopaschuk
Sep 15, 2005·Wiener klinische Wochenschrift·Heinz LeipoldDagmar Bancher-Todesca
Dec 13, 2006·European Heart Journal·Sandra UllmoErik J Meijboom
Apr 15, 2008·Cardiology in the Young·Maria Amélia Bulhões HatémRafaella Petracco
Aug 5, 2008·American Journal of Obstetrics and Gynecology·Adolfo CorreaE Albert Reece
Dec 9, 2008·The Biochemical Journal·Michael P Murphy
Feb 12, 2009·Seminars in Fetal & Neonatal Medicine·Umberto Simeoni, David J Barker
Jun 18, 2009·American Journal of Physiology. Endocrinology and Metabolism·Louis Hue, Heinrich Taegtmeyer
Oct 8, 2009·The Journal of Clinical Endocrinology and Metabolism·Montserrat BalsellsR Corcoy
Jan 15, 2010·JAMA : the Journal of the American Medical Association·Katherine M FlegalLester R Curtin
Jan 21, 2010·Physiological Reviews·Gary D LopaschukWilliam C Stanley
May 1, 2010·American Journal of Obstetrics and Gynecology·Thomas R Moore
May 28, 2010·Journal of Cardiovascular Pharmacology·Gary D Lopaschuk, Jagdip S Jaswal
Sep 14, 2010·Best Practice & Research. Clinical Endocrinology & Metabolism·Emilio Herrera, Henar Ortega-Senovilla
Jan 25, 2011·Biochimica Et Biophysica Acta·Jennifer G Duncan
Feb 4, 2011·American Journal of Obstetrics and Gynecology·Patrick M Catalano, Sylvie Hauguel-De Mouzon
Jun 21, 2011·American Journal of Physiology. Heart and Circulatory Physiology·Anne R DiersNeil Hogg
Dec 24, 2011·Cold Spring Harbor Symposia on Quantitative Biology·D C Wallace
Jun 12, 2012·Cell Metabolism·Ira J GoldbergP Christian Schulze
Sep 5, 2012·Biological Chemistry·Wen-Xing Ding, Xiao-Ming Yin
Sep 18, 2012·Journal of Molecular and Cellular Cardiology·Maolong DongJun Ren
Oct 25, 2012·Physiological Genomics·Ryan D ReadnowerSteven P Jones
Jan 31, 2014·Diabetologia·Heiko Bugger, E Dale Abel
May 20, 2014·Pathology, Research and Practice·Takaya Nakanishi, Seiya Kato
Aug 15, 2014·Journal of Molecular Endocrinology·Melisa KurtzAlicia Jawerbaum
Dec 3, 2014·Biochimica Et Biophysica Acta·Shona A MookerjeeMartin D Brand

❮ Previous
Next ❯

Citations

Nov 23, 2017·Pediatric Research·Eli J LouwagieMichelle L Baack
May 3, 2018·Physiological Reviews·Charles A DucsayLubo Zhang
Jun 19, 2018·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Yazdan GhandiAli Nematinejad
Apr 30, 2020·Proceedings. Biological Sciences·Lauren E GyllenhammerPathik D Wadhwa
Oct 23, 2018·Medicina·Marlon E Cerf
May 12, 2019·International Journal of Obesity : Journal of the International Association for the Study of Obesity·Owen R VaughanThomas Jansson
Nov 16, 2018·Medicina·Marlon E Cerf
Jul 22, 2019·Current Diabetes Reports·Elvira Isganaitis
Aug 9, 2016·Current Opinion in Lipidology·Elena Loche, Susan E Ozanne
Mar 7, 2021·International Journal of Molecular Sciences·Eli J LouwagieMichelle L Baack
Jun 17, 2020·The American Journal of the Medical Sciences·Larysa Aleksenko, Isaac K Quaye
Jun 2, 2021·European Journal of Clinical Investigation·Luís F GriloSusana P Pereira
Sep 24, 2021·Diabetic Medicine : a Journal of the British Diabetic Association·Josca Mariëtte Schoonejans, Susan Elizabeth Ozanne

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

Cardiovascular Disorder in Diabetes

Diabetes is associated with an increased risk of cardiovascular disorders and heart failure. Discover the latest research here.

Related Papers

Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme
V L FootM R Christie
Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte
Jun RenJames R Sowers
© 2022 Meta ULC. All rights reserved