Maternal High-fat Diet Programs Offspring Emotional Behavior in Adulthood

Neuroscience
Gudrun WintherGregers Wegener

Abstract

Prenatal exposure to high-fat diet (HFD) might predispose offspring to develop metabolic and mental disorders later in life. Insight into the molecular and behavioral consequences of maternal HFD on offspring is sparse but may involve both neuroinflammation and a dysregulated neuroendocrine stress axis. Thus, the aim of this work was to: (i) investigate the influence of maternal HFD on memory, anxiety and depression-like behavior in adult offspring and (ii) identify possible biological biomarkers related to neuroinflammation and stress responses. Seven-week-old, female Sprague-Dawley rats received a control diet or a HFD eight weeks prior to conception and during gestation and lactation. We investigated the phenotype of the offspring in the in elevated plus maze, forced swim test, novel object recognition and open field test. Furthermore, hippocampal gene expression related to neuroinflammation and the stress axis was quantitated by real-time qPCR. We found that maternal HFD led to an anxiogenic offspring phenotype in the elevated plus maze, independent of sex. This behavioral alteration was accompanied by significantly higher mRNA levels of the hippocampal pro-inflammatory cytokine tumor necrosis factor-alpha (TNF-α) mRNA and ...Continue Reading

Citations

Nov 23, 2018·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Andrea G EdlowStaci Bilbo
May 25, 2020·Nutrition Reviews·Kinga GawlińskaEdmund Przegaliński
Mar 15, 2019·Nutrients·Ana Laura de la GarzaAlberto Camacho
Jul 14, 2020·Frontiers in Cell and Developmental Biology·Ivo Vieira de Sousa NetoRita de Cassia Marqueti
Nov 30, 2020·Journal of Perinatology : Official Journal of the California Perinatal Association·Lilin Tong, Brian T Kalish
Jan 21, 2021·Nutrients·Kyoko HasebeMargaret J Morris
Nov 25, 2020·Developmental Cognitive Neuroscience·Kinga GawlińskaEdmund Przegaliński
Dec 3, 2020·Journal of the American Academy of Child and Adolescent Psychiatry·Jessica DeightonMiranda Wolpert
Feb 12, 2021·Journal of Medicinal Food·Bianca Romero-DelgadoAna Laura de la Garza
Feb 5, 2021·Frontiers in Cellular Neuroscience·Maude BordeleauMarie-Ève Tremblay
Feb 23, 2020·Frontiers in Neuroendocrinology·Seva G KhambadkoneKellie L K Tamashiro
Mar 2, 2021·Frontiers in Neuroscience·Linda TsanScott E Kanoski
Mar 9, 2021·Pharmacology, Biochemistry, and Behavior·Parker KnightAdriaan W Bruijnzeel
Apr 16, 2021·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Jozef MizeraLucyna Pomierny-Chamiolo
Apr 1, 2021·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Luana Olegário da SilvaLígia Cristina Monteiro Galindo
May 22, 2021·Behavioural Brain Research·Arthur Rocha-GomesHércules Ribeiro Leite
Jul 30, 2021·Neuroscience and Biobehavioral Reviews·Minerva Ortiz-ValladaresNorma Angélica Moy-López

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.