Maternal high-fat diet reversal improves placental hemodynamics in a nonhuman primate model of diet-induced obesity.

International Journal of Obesity : Journal of the International Association for the Study of Obesity
Jennifer A SalatiAntonio E Frias

Abstract

In a Japanese macaque model of diet-induced obesity, we have previously demonstrated that consumption of a high-fat, "Western-style" diet (WSD) is associated with placental dysfunction and adverse pregnancy outcomes, independent of an obese maternal phenotype. Specifically, we have reported decreased uterine placental blood flow and increased inflammation with maternal WSD consumption. We also previously investigated the use of a promising therapeutic intervention that mitigated the adverse placental effects of a WSD but had unexpected detrimental effects on fetal pancreatic development. Thus, the objective of the current study was to determine whether simple preconception diet reversal (REV) would improve placental function. Female Japanese macaques were divided into three groups: REV animals (n = 5) were switched from a chronic WSD (36% fat) to a low fat, CON diet (14% fat) prior to conception and throughout pregnancy. The CON (n = 6) and WSD (n = 6) cohorts were maintained on their respective diets throughout pregnancy. Maternal body weight and composition were regularly assessed and advanced noninvasive imaging was performed at midgestation (gestational day 90, G90, or 0.5 of gestation, where full term is G175), and G129, 1...Continue Reading

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Citations

Aug 5, 2020·Journal of Developmental Origins of Health and Disease·Yutthapong Tongpob, Caitlin Wyrwoll
Sep 5, 2020·BioTechniques·Victoria Hj Roberts, Antonio E Frias
Aug 17, 2021·Theriogenology·Priscila SilvaMarcus Antônio Rossi Feliciano

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Methods Mentioned

BETA
imaging techniques
X-ray
sedation
biopsy
antibody array
ELISA

Software Mentioned

QDR
newCAST
GraphPad Prism

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