Maternal high-fat diet triggers lipotoxicity in the fetal livers of nonhuman primates.

The Journal of Clinical Investigation
Carrie E McCurdyKevin L Grove

Abstract

Maternal obesity is thought to increase the offspring's risk of juvenile obesity and metabolic diseases; however, the mechanism(s) whereby excess maternal nutrition affects fetal development remain poorly understood. Here, we investigated in nonhuman primates the effect of chronic high-fat diet (HFD) on the development of fetal metabolic systems. We found that fetal offspring from both lean and obese mothers chronically consuming a HFD had a 3-fold increase in liver triglycerides (TGs). In addition, fetal offspring from HFD-fed mothers (O-HFD) showed increased evidence of hepatic oxidative stress early in the third trimester, consistent with the development of nonalcoholic fatty liver disease (NAFLD). O-HFD animals also exhibited elevated hepatic expression of gluconeogenic enzymes and transcription factors. Furthermore, fetal glycerol levels were 2-fold higher in O-HFD animals than in control fetal offspring and correlated with maternal levels. The increased fetal hepatic TG levels persisted at P180, concurrent with a 2-fold increase in percent body fat. Importantly, reversing the maternal HFD to a low-fat diet during a subsequent pregnancy improved fetal hepatic TG levels and partially normalized gluconeogenic enzyme expressi...Continue Reading

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Citations

Mar 21, 2012·Reviews in Endocrine & Metabolic Disorders·Malgorzata S Martin-Gronert, Susan E Ozanne
Dec 5, 2012·International Journal of Obesity : Journal of the International Association for the Study of Obesity·J T BrozinickK Grove
Mar 28, 2012·International Journal of Obesity : Journal of the International Association for the Study of Obesity·L FanK L Grove
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Sep 18, 2012·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Melissa A SuterKjersti M Aagaard
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Methods Mentioned

BETA
X-ray
cesarean section
Profiler
biopsies
PCR
sedation
Protein Assay

Software Mentioned

Proteome Profiler
AlphaEaseFC

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