Maternal high-fat diet up-regulates type-1 cannabinoid receptor with estrogen signaling changes in a sex- and depot- specific manner in white adipose tissue of adult rat offspring.

European Journal of Nutrition
Mariana Macedo De AlmeidaI H Trevenzoli

Abstract

Obesity and high-fat (HF) diet are associated with over activation of the endocannabinoid system (ECS). We have demonstrated that maternal HF diet induces early obesity and modulates cannabinoid signaling in visceral (VIS) and subcutaneous (SUB) white adipose tissue (WAT) in weanling rat offspring. We hypothesized that perinatal maternal HF diet would program the expression of ECS in adipose tissue in a long-term way in parallel to alterations in epigenetic markers and sex hormone signaling. Progenitor female rats received control diet (C, 9% fat) or isocaloric high-fat diet (HF, 28% fat) for 8 weeks before mating, gestation, and lactation. All pups were weaned to C diet and they were euthanized at 180 days old. Maternal HF diet induced overweight and increased SUB WAT mass of male and female adult offspring. Maternal HF diet induced hypertrophy of VIS and SUB adipocytes only in female offspring associated with increased type 1 cannabinoid receptor protein (CB1) and mRNA (Cnr1) levels. These changes were associated with increased estrogen receptor α binding to Cnr1 promoter in SUB WAT of adult female offspring, which may contribute to higher expression of Cnr1. Increased CB1 signaling in adipose tissue might contribute to highe...Continue Reading

References

Sep 4, 2003·Genome Biology·Dov GreenbaumMark Gerstein
Dec 5, 2006·Trends in Endocrinology and Metabolism : TEM·Isabel Matias, Vincenzo Di Marzo
Mar 1, 2007·Advances in Physiology Education·Margaret E Wierman
Oct 20, 2007·The Journal of Steroid Biochemistry and Molecular Biology·Karine BlouinAndré Tchernof
May 6, 2008·Nature·Kirsty L SpaldingPeter Arner
Aug 7, 2009·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·M Mohsen Ibrahim
Mar 18, 2011·Journal of Cellular Physiology·Maria C ProtoMaurizio Bifulco
Mar 23, 2011·Birth Defects Research. Part A, Clinical and Molecular Teratology·Lisa A Joss-MooreRobert H Lane
Jul 18, 2012·Cellular and Molecular Life Sciences : CMLS·Paola GrimaldiMauro Maccarrone
Sep 18, 2012·Climacteric : the Journal of the International Menopause Society·S R DavisUNKNOWN Writing Group of the International Menopause Society for World Menopause Day 2012
Nov 21, 2012·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Stefanie SeisenbergerWolf Reik
Mar 12, 2013·Journal of Pregnancy·Bonnie BrensekeJ Claudio Gutierrez
Apr 9, 2013·Cell Metabolism·Cristoforo Silvestri, Vincenzo Di Marzo
Aug 31, 2013·Adipocyte·Osman S OsmanKenneth Langlands
Apr 23, 2014·BioFactors·Luigia CristinoVincenzo Di Marzo
Sep 1, 2014·Neuroscience and Biobehavioral Reviews·C D'AddarioM Maccarrone
Sep 26, 2014·Molecular Biology Reports·Ernesto BurgioLucia Migliore
Nov 5, 2014·Nature Reviews. Endocrinology·Fredrik Karpe, Katherine E Pinnick
Dec 11, 2014·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Lisa A Joss-MooreKurt H Albertine
Dec 24, 2014·The Journal of Nutritional Biochemistry·Andrea Di FrancescoClaudio D'Addario
Jan 13, 2015·Molecular and Cellular Endocrinology·Biff F Palmer, Deborah J Clegg
Mar 23, 2015·Trends in Pharmacological Sciences·Mauro MaccarroneAndreas Zimmer
Apr 11, 2015·Journal of Developmental Origins of Health and Disease·K A Lillycrop, G C Burdge
Mar 29, 2016·Journal of the Academy of Nutrition and Dietetics·Jamie Stang, Laurel G Huffman
Jul 27, 2017·The Journal of Steroid Biochemistry and Molecular Biology·J MaiaB M Fonseca
Jun 1, 2018·Neonatology·Umberto SimeoniJean-François Tolsa
Aug 12, 2018·Journal of Lipid Research·Aaron P FrankDeborah J Clegg
Mar 28, 2019·Frontiers in Endocrinology·Peter Mancuso, Benjamin Bouchard

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