Maternal hyperlipidemia and the risk of preeclampsia: a meta-analysis

American Journal of Epidemiology
Cassandra N SpracklenKelli K Ryckman

Abstract

Published reports examining lipid levels during pregnancy and preeclampsia have been inconsistent. The objective of this meta-analysis was to test the association between preeclampsia and maternal total cholesterol, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), non-HDL-C, and triglyceride levels measured during pregnancy. We conducted a systematic search for studies published between the index date until July 2013 reporting maternal lipid levels in women with preeclampsia and normotensive pregnant women. Seventy-four studies met all eligibility criteria and were included in the meta-analysis. Weighted mean differences in lipid levels were calculated using a random-effects model. Statistical heterogeneity was investigated using the I(2) statistic. Meta-regression was used to identify sources of heterogeneity. Preeclampsia was associated with elevated total cholesterol, non-HDL-C, and triglyceride levels, regardless of gestational age at the time of blood sampling, and with lower levels of HDL-C in the third trimester. A marginal association was found with LDL-C levels. Statistical heterogeneity was detected in all analyses. Meta-regression analyses suggested that differences in body m...Continue Reading

References

Jul 1, 1989·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·U RosingA Kallner
Nov 1, 1989·American Journal of Obstetrics and Gynecology·J M RobertsM K McLaughlin
Dec 1, 1966·Clinical Obstetrics and Gynecology·G H Nelson
Jul 1, 1995·British Journal of Obstetrics and Gynaecology·B LorentzenT Henriksen
Nov 1, 1996·American Journal of Obstetrics and Gynecology·R B Ness, J M Roberts
Aug 1, 1997·Metabolism: Clinical and Experimental·J T MuraiR N Taylor
Jul 9, 1998·Seminars in Reproductive Endocrinology·B Lorentzen, T Henriksen
Dec 17, 1998·American Journal of Obstetrics and Gynecology·Robert W PowersJ M Roberts
Dec 10, 1999·European Journal of Obstetrics, Gynecology, and Reproductive Biology·R MadazliF Aksu
Dec 22, 1999·Proceedings of the Society for Experimental Biology and Medicine·C A Hubel
Feb 5, 2000·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·S Ware-JaureguiMichelle A Williams
Feb 24, 2001·Lancet·J M Roberts, D W Cooper
Aug 15, 2002·Hypertension in Pregnancy : Official Journal of the International Society for the Study of Hypertension in Pregnancy·Jeanne FrancoualRené Frydman
Dec 18, 2002·Circulation·Paul J Wang, N A Mark Estes
Jan 9, 2003·Hypertension in Pregnancy : Official Journal of the International Society for the Study of Hypertension in Pregnancy·Jacqueline ChalasAlbert Lindenbaum
Oct 18, 2003·Clinical Biochemistry·Mustafa Baki CekmenSevinc Kuskay
Dec 23, 2003·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Luís BeloIrene Rebelo
May 18, 2004·Acta Obstetricia Et Gynecologica Scandinavica·Dorothy J VanderjagtRobert H Glew
Jul 6, 2004·American Journal of Hypertension·Daniel A EnquobahrieDavid A Luthy
Jul 17, 2004·Free Radical Biology & Medicine·Elisa LlurbaCarmen Dominguez
Feb 25, 2005·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Y KocyigitZeki Akkus
Jul 29, 2005·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Gokhan BayhanZeki Akkus
Aug 10, 2005·Gynecologic and Obstetric Investigation·H UzunM Albayrak
Sep 24, 2005·Obstetrics and Gynecology·ACOG Committee on Practice Bulletins--Obstetrics
Apr 11, 2006·Clinical Biochemistry·Carole B RudraMichelle A Williams
Apr 15, 2006·Hypertension in Pregnancy : Official Journal of the International Society for the Study of Hypertension in Pregnancy·Saeideh ZiaeiAnoshirvan Kazemnejad
Sep 5, 2006·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Young Ju KimMyung-Geol Pang
Oct 27, 2007·Journal of the Chinese Medical Association : JCMA·Usha AdigaNandini Mangalore
Nov 3, 2007·BMJ : British Medical Journal·Elisabeth Balstad MagnussenPål Richard Romundstad
Nov 6, 2007·Clinical Obstetrics and Gynecology·Kristine Y Lain, Patrick M Catalano
Feb 9, 2008·Hypertension·Leona C Y PoonKypros H Nicolaides
Jun 21, 2008·Arteriosclerosis, Thrombosis, and Vascular Biology·Martin AdielsJan Borén
Jul 16, 2008·The Journal of Surgical Research·John H TinsleyEd W Childs
Sep 16, 2008·Trends in Cardiovascular Medicine·David M CartyAnna F Dominiczak
Oct 14, 2008·Metabolic Syndrome and Related Disorders·Carlos Antonio NegratoMarilza Vieira Cunha Rudge
Feb 24, 2009·Reproductive Sciences·Ahmet Basaran
Mar 21, 2009·Archives of Gynecology and Obstetrics·Banu DaneAhmet Cetin
May 26, 2009·Seminars in Perinatology·Lelia Duley
Jul 28, 2009·Journal of Clinical Epidemiology·David MoherPRISMA Group
Sep 17, 2009·Bosnian Journal of Basic Medical Sciences·Milan StefanovićAleksandra Tubić-Pavlović
Jan 7, 2010·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Sofoklis SamolisGeorge Maroulis
Jan 16, 2010·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Toshitaka MoriAi Fujimaki
Mar 12, 2010·Journal of Human Hypertension·Q LeiJ M Niu
Mar 25, 2010·American Journal of Reproductive Immunology : AJRI·Christopher W G Redman, Ian L Sargent
Apr 7, 2010·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Rui-zhe JiaHai-qing Wu
Jun 11, 2010·Nutrition Research·Eun-Kyung KimEun Mi Kim
Jan 14, 2011·Archives of Physiology and Biochemistry·B H KandimallaS S Maiya
Jan 22, 2011·Hypertension in Pregnancy : Official Journal of the International Society for the Study of Hypertension in Pregnancy·Ulrich PecksWerner Rath
Jun 17, 2011·The Journal of Obstetrics and Gynaecology Research·Oya DemirciSadiye Eren
Oct 12, 2011·The Journal of International Medical Research·B DemirG Toprak
Dec 1, 2011·Advances in Clinical Chemistry·Alessandra GhioGraziano Di Cianni
Feb 11, 2012·Journal of the American College of Cardiology·Scott M Grundy
Feb 23, 2012·The Journal of Obstetrics and Gynaecology Research·Laura M ReyesPatricio López-Jaramillo
Mar 3, 2012·The Journal of Obstetrics and Gynaecology Research·Rose GasnierJosé Geraldo L Ramos
Apr 11, 2012·Growth Factors·Laura M ReyesPatricio López-Jaramillo
Jun 28, 2012·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Jianjun ZhouYali Hu
Aug 2, 2012·Journal of Obstetrics and Gynaecology of India·J T GohilPriyanka Gupta
Aug 23, 2012·PloS One·Laura M ReyesPatricio López-Jaramillo
Feb 5, 2013·North American Journal of Medical Sciences·Madhusudan DeyReema Kumar
Feb 12, 2013·European Journal of Epidemiology·Morven Caroline BrownRuth Bell
Mar 6, 2013·Hypertension·Anne Cathrine StaffChristopher W G Redman
Apr 30, 2013·Archives of Gynecology and Obstetrics·M O AkiibinuS O Akiibinu
Jul 19, 2013·BJOG : an International Journal of Obstetrics and Gynaecology·I D GallosM Vatish
Nov 26, 2013·Heart, Lung & Circulation·Francesca CharltonAnnemarie Hennessy
Jan 11, 2014·Journal of Hypertension·Amita A MahendruCarmel M McEniery
Apr 1, 2012·Pregnancy Hypertension·Saeideh ZiaeiAnoshirvan Kazemnejad

Citations

May 24, 2015·American Journal of Hypertension·Caitlin J SmithKelli K Ryckman
Feb 26, 2016·Hypertension in Pregnancy : Official Journal of the International Society for the Study of Hypertension in Pregnancy·Shi-Sheng ZhouNa-Na Chen
Dec 20, 2014·American Journal of Hypertension·Cassandra N SpracklenKelli K Ryckman
Feb 26, 2016·Maternal and Child Health Journal·Cassandra N SpracklenAudrey F Saftlas
May 6, 2016·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Yu-Chun ZhuLi-Jun Yu
Mar 16, 2017·Annals of Nutrition & Metabolism·Zhandong ZengShixian Li
Oct 5, 2017·Acta Diabetologica·Paweł GutajEwa Wender-Ożegowska
Apr 20, 2018·Expert Opinion on Investigational Drugs·Serban M MaiereanMaciej Banach
Oct 28, 2016·Journal of Perinatology : Official Journal of the California Perinatal Association·C WangHuixia Yang
Jul 14, 2018·Journal of Women's Health·Kathryn E FayNeil J Stone
Feb 2, 2019·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Margaret Olutayo AleseThajasvarie Naicker
Jan 5, 2018·European Journal of Nutrition·Xueling XinDongfeng Zhang
Mar 7, 2019·PloS One·Márcia Aires Rodrigues de FreitasNilson Penha-Silva
Oct 16, 2018·Minerva ginecologica·Dimitrios NasioudisTomi T Kanninen
Apr 18, 2019·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Dorien ReijndersJenny L Sones
Jan 10, 2018·The Journal of Obstetrics and Gynaecology Research·Yan-Ping LinZi-Shun Li
Sep 30, 2018·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·R TownsendIPPIC Network
Jul 26, 2019·The Journal of Physiology·Wilfried Gyselaers, Basky Thilaganathan
Jun 21, 2019·The Journal of Clinical Endocrinology and Metabolism·Clare B KellyTimothy J Lyons
Nov 27, 2019·Clinical Obstetrics and Gynecology·Suchitra Chandrasekaran, Rebecca Simon
Apr 16, 2020·Hypertension in Pregnancy : Official Journal of the International Society for the Study of Hypertension in Pregnancy·Morteza AbyadehSakineh Shab-Bidar
Oct 9, 2019·Journal of Clinical Medicine·Rachael FoxAdam J Lewandowski
Aug 3, 2020·BJOG : an International Journal of Obstetrics and Gynaecology·K J GrayR Saxena
Jul 6, 2017·Biosensors·Jessica Z Kubicek-SutherlandHarshini Mukundan
Apr 25, 2018·Obstetrics and Gynecology International·Márcia Aires Rodrigues de FreitasNilson Penha-Silva
Jan 18, 2017·International Journal of Obesity : Journal of the International Association for the Study of Obesity·K M RenaultK Nørgaard
Dec 1, 2018·Frontiers in Endocrinology·Hui LiuDongfeng Zhang
Apr 13, 2019·Lipids in Health and Disease·Yulong LiHui Yuan
Oct 14, 2018·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Su-A KimJeong Bae Park
Nov 26, 2019·The Pan African Medical Journal·Anissa Ben AmorAmel Triki
Dec 29, 2020·Ecotoxicology and Environmental Safety·Teresa Dalla ZuannaCristina Canova
Dec 15, 2020·Clínica e investigación en arteriosclerosis : publicación oficial de la Sociedad Española de Arteriosclerosis·Marta MauriDaiana Ibarretxe
Dec 11, 2019·Atherosclerosis. Supplements·Christine ContiniKarl Winkler
Aug 10, 2020·American Journal of Obstetrics and Gynecology·Amanda M PerakHyperglycemia and Adverse Pregnancy Outcome (HAPO) Study Cooperative Research Group
Nov 23, 2020·Pregnancy Hypertension·Noora JaatinenEeva Ekholm
Mar 7, 2021·BMJ Open Diabetes Research & Care·Manjunath RamanjaneyaAbdul Badi Abou-Samra
Feb 25, 2021·European Journal of Preventive Cardiology·Reed MszarKhurram Nasir
Apr 8, 2021·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Wang JingYangYu Zhao
Nov 24, 2020·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Nicola ZamaiBarbara J Meyer
May 1, 2021·Frontiers in Endocrinology·María Fernanda GarcesJorge Eduardo Caminos
Apr 15, 2021·American Journal of Obstetrics and Gynecology·Sushila AryaNICHD’s Reproductive Medicine Network

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