PMID: 8832Jan 1, 1976

Maternal immunocompetence. I. The graft-versus-host reactivity of lymphocytes from pregnant rats and the distribution pattern of 51Cr-labeled lymphocytes in pregnant mice

Scandinavian Journal of Immunology
M R Harrison


Lymphocytes from the peripheral blood, spleen, or para-aortic lymph nodes of prrimigravida L rats carrying (L X BN) F1 (LBN) fetuses are fully capable of mounting graft-versus-host (GVH) reactions in LBN F1 recipients. The reactivity of lymphocytes from interstrain pregnant (L X BN) or intrastrain pregnant (L X L) rats, or from rats postpartum from these pregnancies, is equivalent to that of normal virgin females over a full dose-response curve, ruling out both specific and nonspecific effects of pregnancy on the intrinsic GVH competence of the maternal thymus-derived (T) lymphocyte. Attempts to block GVH reactivity with serum from pregnant rats were unsuccessful. In addition, when the distribution pattern of 51Cr-labeled syngeneic and semiallogeneic lymphocytes was studied in intact primigravida mice, there was no difference between interstrain and intrastrain pregnant mice, and there was no evidence of immunologically specific 'trapping' in the para-aortic lymph nodes draining the interstrain pregnant uterus.


Jan 8, 1972·Lancet·J K SmithE J Field
Sep 20, 1973·The New England Journal of Medicine·Y H ThongJ A Bellanti
Dec 22, 1971·Nature: New Biology·M M Zatz, E M Lance
Dec 1, 1973·The Journal of Experimental Medicine·M R Harrison, W E Paul
Apr 1, 1972·Transplantation·B F Heslop, B E Hardy
Apr 1, 1972·The Journal of Experimental Medicine·A E BeerS L Yang
Jan 19, 1973·Science·A E Beer, R E Billingham
Feb 1, 1973·Transplantation·H Patthey, M Edidin
Oct 1, 1970·The Journal of Experimental Medicine·A E Beer, R E Billingham
Jun 1, 1971·The Journal of Experimental Medicine·J PalmR L Brinster
Jul 1, 1971·The Journal of Experimental Medicine·M M Zatz, E M Lance
Sep 15, 1967·American Journal of Obstetrics and Gynecology·R L SIMMONSP S RUSSELL
Mar 15, 1969·Nature·M TuffreyR D Barnes
Mar 1, 1966·Transplantation·D R BainbridgeG Gowland
May 1, 1964·Transplantation·R L SIMMONS, P S RUSSELL


Jan 1, 1980·American Journal of Reproductive Immunology : AJRI·S R Gottesman, O Stutman
Nov 1, 1979·Arthritis and Rheumatism·D P StitesP K Siiteri
Jun 18, 2010·Immunology·Michelle T NortonElizabeth A Bonney

Related Concepts

Graft Vs Host Reaction
Cellular Immune Response
Lymph Nodes
Lymphoid Cells
Mice, Inbred Strains
Pregnancy, Animal
August Rats
Transplantation, Homologous
Isogenic Transplantation

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