Maternal inhibition of infant behavioral response following isolation in novel surroundings and inflammatory challenge.

Developmental Psychobiology
M B HennessyTerrence Deak

Abstract

During isolation in a novel environment, guinea pig pups gradually begin to display passive behavior that appears to be mediated by proinflammatory activity, that is, "sickness behavior.". Administration of substances that increase proinflammatory activity [corticotropin-releasing factor (CRF), lipopolysaccharide (LPS)] prior to isolation induces passive behavior from the beginning of the isolation episode. Here, we show that reunion with the mother in the novel environment rapidly and potently suppresses the passive behavior of isolated pups (Experiment 1); inhibits the passive behavior of pups administered CRF (10 µg, subcutaneous; Experiment 2); and inhibits the passive behavior of male, though not female, pups administered LPS (250 µg/kg, intraperitoneal; Experiment 3). Together these findings suggest that the presence of the mother either recruits other processes that moderate the impact of proinflammatory processes on brain mechanisms mediating the passive response or initiates compensatory mechanisms that counter the effect of proinflammatory activity. Further, the results suggest that for physically ill animals of social species, the adaptive advantage that accrues from maintaining normal social interactions may sometim...Continue Reading

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Citations

Jan 28, 2016·Frontiers in Zoology·Michael B HennessyNorbert Sachser
Nov 5, 2013·Brain, Behavior, and Immunity·Michael B HennessyPatricia A Schiml
Apr 16, 2014·Developmental Psychobiology·Michael B Hennessy
Dec 27, 2016·Frontiers in Endocrinology·Christopher A MurgatroydBenjamin C Nephew
Jan 23, 2019·Frontiers in Behavioral Neuroscience·Michael B HennessyTerrence Deak
Feb 23, 2018·Journal of Psychiatric Research·Jodi L LukkesSusan L Andersen

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