Maternal insulin-like growth factor 1 and 2 differentially affect the renin-angiotensin system during pregnancy in the guinea pig

Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society
Prue StandenClaire T Roberts

Abstract

Insulin-like growth factors (IGFs) are known to interact with the renin-angiotensin system (RAS). We previously demonstrated that administration of IGF1 to guinea pigs in early to mid pregnancy promotes placental function and fetal growth in mid to late gestation. Early administration of IGF2 had sustained, but not acute, effects on these parameters and also on placental structural differentiation. Here, we aimed to determine whether the IGFs interact with the placental RAS in early to mid gestation to modulate placental development and increase fetal growth and survival, and if IGF2 binding the IGF2R is implicated in the sustained effects of IGF2 treatment. At day 20 of pregnancy, guinea pigs were infused with 1m g/kg/day of IGF1, IGF2, (Leu27)IGF2 or vehicle for 18days and sacrificed on either day 62 (late pregnancy) or during the infusion period on day 35 (early-mid pregnancy). Placental structure at day 35 was analyzed using morphometric technique and expression of RAS genes in the placenta and placental and plasma renin activity were measured at both time points. Compared with vehicle at day 35 of gestation, IGF1 infusion reduced the total midsagittal cross-sectional area of the placenta (-17%, p = 0.02) and the labyrinth ...Continue Reading

References

Jan 1, 1979·Biology of the Neonate·E R Lumbers, J L Lewes
Mar 26, 1991·European Journal of Pharmacology·F A Le NobleH A Struyker Boudier
May 1, 1982·The Journal of Clinical Endocrinology and Metabolism·W A HsuehA McHargue
Jan 1, 1995·Prostaglandins·T M Siler-KhodrK A Sorem
Oct 1, 1993·British Journal of Pharmacology·E R LumbersA D Stevens
Dec 26, 2001·Biology of Reproduction·Yang XiaRodney E Kellems
Mar 27, 2002·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·A SohlströmP C Owens
May 2, 2002·The Journal of Biological Chemistry·Yang XiaRodney E Kellems
Oct 15, 2003·The Journal of Clinical Endocrinology and Metabolism·Friederike HerrMarek Zygmunt
Mar 25, 2006·Endocrinology·Amanda N Sferruzzi-PerriClaire T Roberts
Apr 9, 2008·Reproduction : the Official Journal of the Society for the Study of Fertility·D HerrC Wulff
Sep 25, 2009·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Tim Van MieghemJohan Verhaeghe
Aug 25, 2010·Journal of Cellular and Molecular Medicine·Guanghong JiaDevendra K Agrawal
Mar 21, 2012·Nature Reviews. Neuroscience·Ana M Fernandez, Ignacio Torres-Alemán

❮ Previous
Next ❯

Citations

Mar 25, 2017·The Journal of Physiology·Amanda N Sferruzzi-PerriAbigail L Fowden
Apr 16, 2020·Science China. Life Sciences·Tahir MuhammadZi-Jiang Chen

❮ Previous
Next ❯

Related Concepts

Related Feeds

Arterial-Venous in Development & Disease

Arterial-venous development may play a crucial role in cardiovascular diseases. Here is the latest research.