PMID: 8946050Nov 22, 1996Paper

Maternal insulin manipulations in rats organize body weight and noradrenergic innervation of the hypothalamus in gonadally intact male offspring

Brain Research. Developmental Brain Research
A P JonesB States

Abstract

In previous work it has been shown that adult male, but not female, offspring of rats that have been injected with protamine zinc insulin (6 IU/kg) on days 15-20 of gestation, develop significant obesity beginning about 50 days of age. This obesity is accompanied by elevated medial hypothalamic extracellular norepinephrine levels. To examine whether the expression of obesity in male offspring is mediated by perinatal testosterone levels, male offspring of insulin-treated or control dams were either castrated or received sham surgery on postnatal day 1. Castrated male offspring of insulin-treated dams did not become obese like their gonadally intact male littermates. This suggests that perinatal testosterone levels may interact with developmental processes mediating the obesity in male offspring of insulin-treated dams. A second question addressed was whether the elevated hypothalamic extracellular norepinephrine levels observed in our earlier work are evident as morphological changes in norepinephrine-containing systems in the medial hypothalamus and locus coeruleus. We found a significant enhancement of dopamine-beta-hydroxylase immunoreactivity in fibers innervating the paraventricular nucleus of the hypothalamus in 121-day-o...Continue Reading

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Mar 5, 2008·Psychopharmacology·Regina C CasperLaurence Tecott
Jun 24, 2003·Physiology & Behavior·Kevin L Grove, M Susan Smith
Sep 5, 1998·Brain Research. Developmental Brain Research·A PlagemannG Dörner
Jul 4, 2006·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Barry E Levin
Sep 14, 2011·Annual Review of Physiology·Paolo Rinaudo, Erica Wang
Jan 30, 2013·Frontiers in Neuroendocrinology·Sebastien G Bouret
Nov 9, 2011·Diabetes Research and Clinical Practice·Wing Hung TamJuliana Chung Ngor Chan
Aug 8, 2007·Journal of the Cardiometabolic Syndrome·Michael Bursztyn, Ilana Ariel
Apr 17, 2010·Physiology & Behavior·Kellie L K Tamashiro, Timothy H Moran
Nov 6, 2004·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Barry E Levin
Feb 12, 2005·The Journal of Physiology·I Caroline McMillenBeverly S Mühlhäusler
Mar 25, 2005·Physiological Reviews·I Caroline McMillen, Jeffrey S Robinson
Feb 28, 2009·Journal of Pediatric Gastroenterology and Nutrition·Sebastien G Bouret
Jul 1, 1997·The British Journal of Nutrition·P R ShepherdS E Ozanne
Sep 21, 2013·American Journal of Physiology. Endocrinology and Metabolism·Marie-Amélie LukaszewskiChristophe Breton
Oct 12, 2002·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Barry E Levin, Ambrose A Dunn-Meynell
Mar 30, 2017·Saudi Journal of Kidney Diseases and Transplantation : an Official Publication of the Saudi Center for Organ Transplantation, Saudi Arabia·Huma AsmatWaqar Kashif
Jun 29, 2007·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Barry E Levin
Jan 14, 2021·Journal of Neuroendocrinology·Laura DeardenSusan E Ozanne
Oct 2, 1998·The American Journal of Physiology·B E Levin, E Govek

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