Maternal intake of quercetin during gestation alters ex vivo benzo[a]pyrene metabolism and DNA adduct formation in adult offspring

Mutagenesis
Kimberly VanheesRoger W L Godschalk

Abstract

Variation in xenobiotic metabolism cannot entirely be explained by genetic diversity in metabolic enzymes. We suggest that maternal diet during gestation can contribute to variation in metabolism by creating an in utero environment that shapes the offspring's defence against chemical carcinogens. Therefore, pregnant mice were supplemented with the natural aryl hydrocarbon receptor (AhR) agonist quercetin (1 mmol quercetin/kg feed) until delivery. Next, it was investigated whether the adult offspring at the age of 12 weeks had altered biotransformation of the environmental pollutant benzo[a]pyrene (B[a]P). In utero quercetin exposure resulted in significantly enhanced gene expression of Cyp1a1, Cyp1b1, Nqo1 and Ugt1a6 in liver of foetuses at Day 14.5 of gestation. Despite cessation of supplementation after delivery, altered gene expression persisted into adulthood, but in a tissue- and gender-dependent manner. Expression of Phase I enzymes (Cyp1a1 and Cyp1b1) was up-regulated in the liver of adult female mice in utero exposed to quercetin, whereas expression of Phase II enzymes (Gstp1, Nqo1 and Ugt1a6) was predominantly enhanced in the lung tissue of female mice. Epigenetic mechanisms may contribute to this adapted gene expressi...Continue Reading

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Citations

May 3, 2014·Journal of Medicinal Food·Germán Chamorro-CevallosGabriela Gutiérrez-Salmeán
Jul 31, 2013·Cellular and Molecular Life Sciences : CMLS·Kimberly VanheesRoger W L Godschalk
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Mar 7, 2020·International Journal of Environmental Research and Public Health·Mei-Hsin HsuLi-Tung Huang
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Oct 25, 2020·Antioxidants·Nesrein M HashemJesus Simal-Gandara

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