Maternal Iodine Status and Associations with Birth Outcomes in Three Major Cities in the United Kingdom

Nutrients
Charles J P SnartLaura J Hardie

Abstract

Severe iodine deficiency in mothers is known to impair foetal development. Pregnant women in the UK may be iodine insufficient, but recent assessments of iodine status are limited. This study assessed maternal urinary iodine concentrations (UIC) and birth outcomes in three UK cities. Spot urines were collected from 541 women in London, Manchester and Leeds from 2004⁻2008 as part of the Screening for Pregnancy End points (SCOPE) study. UIC at 15 and 20 weeks' gestation was estimated using inductively coupled plasma-mass spectrometry (ICP-MS). Associations were estimated between iodine status (UIC and iodine-to-creatinine ratio) and birth weight, birth weight centile (primary outcome), small for gestational age (SGA) and spontaneous preterm birth. Median UIC was highest in Manchester (139 μg/L, 95% confidence intervals (CI): 126, 158) and London (130 μg/L, 95% CI: 114, 177) and lowest in Leeds (116 μg/L, 95% CI: 99, 135), but the proportion with UIC <50 µg/L was <20% in all three cities. No evidence of an association was observed between UIC and birth weight centile (-0.2% per 50 μg/L increase in UIC, 95% CI: -1.3, 0.8), nor with odds of spontaneous preterm birth (odds ratio = 1.00, 95% CI: 0.84, 1.20). Given the finding of iodin...Continue Reading

Associated Clinical Trials

References

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Citations

Jan 16, 2020·Journal of Clinical Medicine·Inés VelascoEduardo García-Fuentes
Jun 12, 2020·BMC Medicine·Charles Jonathan Peter SnartLaura J Hardie
Dec 6, 2020·BMC Pediatrics·Kirsten Jade CromieDarren Charles Greenwood
Nov 14, 2020·European Journal of Clinical Nutrition·Jessica FarebrotherAngela C Flynn
Apr 4, 2021·Nutrients·Maria Teresa Murillo-LlorenteMarcelino Pérez-Bermejo
Jul 12, 2021·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Isabela M BenseñorPaulo A Lotufo

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BETA
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NCT02357667

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