Maternal iodine status, intrauterine growth, birth outcomes and congenital anomalies in a UK birth cohort

BMC Medicine
Charles Jonathan Peter SnartLaura J Hardie

Abstract

Severe iodine insufficiency in pregnancy has significant consequences, but there is inadequate evidence to indicate what constitutes mild or moderate insufficiency, in terms of observed detrimental effects on pregnancy or birth outcomes. A limited number of studies have examined iodine status and birth outcomes, finding inconsistent evidence for specific outcomes. Maternal iodine status was estimated from spot urine samples collected at 26-28 weeks' gestation from 6971 mothers in the Born in Bradford birth cohort. Associations with outcomes were examined for both urinary iodine concentration (UIC) and iodine-to-creatinine ratio (I:Cr). Outcomes assessed included customised birthweight (primary outcome), birthweight, small for gestational age (SGA), low birthweight, head circumference and APGAR score. There was a small positive association between I:Cr and birthweight in adjusted analyses. For a typical participant, the predicted birthweight centile at the 25th percentile of I:Cr (59 μg/g) was 2.7 percentage points lower than that at the 75th percentile of I:Cr (121 μg/g) (99% confidence interval (CI) 0.8 to 4.6), birthweight was predicted to be 41 g lower (99% CI 13 to 69) and the predicted probability of SGA was 1.9 percentage...Continue Reading

Associated Clinical Trials

References

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Citations

Nov 30, 2020·Clinical Endocrinology·Jayne V Woodside, Karen R Mullan
Nov 14, 2020·European Journal of Clinical Nutrition·Jessica FarebrotherAngela C Flynn
Sep 25, 2021·Metabolomics : Official Journal of the Metabolomic Society·Daniel R McKeatingAnthony V Perkins
Oct 3, 2021·Archives of Gynecology and Obstetrics·Yaniv S OvadiaSimon Shenhav

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Methods Mentioned

BETA
SGA

Clinical Trials Mentioned

NCT03552341

Software Mentioned

GROW
EQUIP

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