Maternal lamotrigine treatment and elevated neonatal gamma-glutamyl transpeptidase

Pediatric Neurology
Gal Dubnov-RazPaul Merlob

Abstract

Lamotrigine is an antiepileptic drug with a low adverse-effect profile. This report describes an infant born to an epileptic mother treated with lamotrigine, who had a highly elevated gamma-glutamyl transpeptidase level after birth. There was no other clinical or biochemical evidence of liver or bile duct dysfunction. Infant serum level of lamotrigine, which crosses the placenta, was within therapeutic limits. Gamma-glutamyl transpeptidase levels declined slowly during the following months. We suggest that, in the absence of additional markers of tissue damage, the infant's gamma-glutamyl transpeptidase elevation was caused by maternal intake of lamotrigine. Liver function tests should be monitored in infants of lamotrigine treated mothers, as enzyme elevation might still suggest liver damage.

References

Jul 1, 1986·Journal of Pediatric Gastroenterology and Nutrition·J DeutschH J Semmelrock
Jan 1, 1997·European Journal of Clinical Pharmacology·B RambeckU Jürgens
May 14, 1998·Epilepsia·Torbjorn TomsonS Vitols
Feb 11, 2000·Pediatric Neurology·M FayadM Mikati
Oct 9, 2002·Epilepsia·Patricia TennisInternational Lamotrigine Pregnancy Registry Scientific Advisory Committee
Dec 22, 2004·Epilepsia·Miyako Oguni, Makiko Osawa

Citations

Mar 18, 2010·Health Promotion International·Katarina HaraldssonBertil Marklund
Oct 7, 2010·Psychiatry and Clinical Neurosciences·Lei ChenSunao Kaneko

Related Concepts

BW-430C
Anticonvulsants
Single Seizure
Gamma-glutamyl transferase
Newborn Physiological Jaundice
Liver Function Tests
Pregnancy Complications
Benzotriazines

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