Maternal levels of serum-soluble CD8 and IL-2R are not significantly elevated in idiopathic preterm labour

European Journal of Obstetrics, Gynecology, and Reproductive Biology
M J DiversR J Lilford

Abstract

To search for evidence of immune activation in idiopathic preterm term labour by measuring the soluble markers of T cell activation, CD8 (sCD8) and interleukin-2 receptor (sIL2R). Serum sCD8 and sIL-2R were measured by commercial ELISA in subjects undergoing idiopathic preterm labour (PTL; n = 15) and normal term labour (TL; n = 17). Two gestationally equivalent non-labouring groups were also included representing preterm (PTC; n = 10) and term (TC; n = 10) controls. Possible delayed responses in soluble activation markers were monitored in blood samples taken 48 h after delivery in both labouring groups (PTLp; n = 9: TLp; n = 9). (1) Excluding the 48 h postpartum samples, no statistically significant differences were revealed following a Kruskall-Wallis analysis of variance (ANOVA) for levels of sIL-2R (P = 0.093) and sCD8 (P = 0.098). Including the postpartum samples, however, gave statistically significant differences for each (sIL-2R: P = 0.033; sCD8: P = 0.006). (2) No statistically significant difference was revealed by direct comparison of the two labouring groups alone (Wilcoxon-Mann-Whitney test: P > 0.05). (3) Significantly lower levels of sCD8 were found in the PTL subgroup which had histological evidence of inflamma...Continue Reading

References

Oct 1, 1991·American Journal of Obstetrics and Gynecology·M A MacLeanJ J Walker
Jun 22, 1989·The New England Journal of Medicine·D E GriffinA Vaisberg
Apr 29, 1989·Lancet·A O'Garra
Oct 13, 1988·The New England Journal of Medicine·S L HillierD A Eschenbach
Sep 1, 1983·The Journal of Experimental Medicine·J FujimotoR Levy

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Citations

Apr 30, 1999·Journal of Reproductive Immunology·D N BurnsR P Nugent

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