Maternal Lipids at 28 Weeks' Gestation and Offspring Adiposity at Age 5 to 7 Years

The Journal of Clinical Endocrinology and Metabolism
Parag K ThawareD R McCance

Abstract

Obesity is a global epidemic, and there is a focus on identifying markers of obesity in children with a view to prevention. We aimed to examine prospectively the association of maternal fasting lipids with adiposity in 5- to 7-year-old offspring in a large observational study. Pregnant women (1612) were recruited to the Belfast center of the Hyperglycemia and Adverse Pregnancy Outcome study in a large tertiary maternity hospital at an average of 28 weeks' gestation. Maternal fasting total cholesterol, low-density lipoprotein-cholesterol, triglycerides, and high-density lipoprotein-cholesterol were estimated at 28 weeks' gestation. Offspring-mother pairs (819) were included in the current study, and adiposity was expressed as body mass index (BMI) z score (1990 British growth standard) and sum of skin-fold (SSF) thicknesses (triceps, subscapular, and suprailiac). Statistical significance was more rigorously defined as P < 0.01 to allow for multiple comparisons. No linear relation was found between maternal lipids and offspring BMI z score or SSFs (P ≥ 0.01) using correlation analysis. With the use of logistic regression, there was no relation between maternal lipids and offspring adiposity controlled for birthweight z score, off...Continue Reading

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