Maternal Low-Protein Diet Impairs Prostate Growth in Young Rat Offspring and Induces Prostate Carcinogenesis With Aging

The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
Sérgio A A SantosLuis A Justulin

Abstract

Carcinogenesis is frequently linked to genetic background, however, exposure to environmental risk factors has gained attention as the etiologic agent for several types of cancer, including prostate. The intrauterine microenvironment has been described as a preponderant factor for offspring health; and maternal exposure to insult has been linked to chronic disease in older offspring. Using a model of maternal exposure to low-protein diet (LPD; 6% protein), we demonstrated that impairment of offspring rat prostatic growth on postnatal day (PND) 21 was associated with prostate carcinogenesis in older offspring (PND 540). One explanation is that maternal LPD consumption exposed offspring to an estrogenic intrauterine microenvironment, which potentially sensitized prostate cells early during glandular morphogenesis, increasing cellular response to estrogen in older rats. The onset of accelerated prostatic growth, observed on PND 21, associated with an unbalanced estrogen/testosterone ratio and increased circulating IGF-1 in older offspring appears to contribute to the development of prostate carcinoma in groups on gestational low protein and gestational and lactational low protein diets (33 and 50%, respectively). Our study strongl...Continue Reading

References

Jul 1, 1966·The Journal of Cell Biology·E R WeibelW F Scherle
Jan 1, 1970·International Journal of Neurology·J D Geissinger, P Bucy
Feb 1, 1971·Archives of Neurology·J D Geissinger
Jan 1, 1994·Breast Cancer Research and Treatment·S E Bulun, E R Simpson
May 1, 1994·The Journal of Urology·B G TimmsL J Didio
Dec 1, 1995·Human Pathology·W A Gardner
Dec 31, 1998·Seminars in Cancer Biology·A Ekbom
Jul 31, 1999·Applied and Environmental Microbiology·L W SintonP A Lynch
Sep 21, 2000·Journal of the National Cancer Institute·H Yu, T Rohan
May 31, 2001·Experimental Animals·M NakazawaN Sumi
Jan 22, 2002·Reproduction, Fertility, and Development·G S PrinsC Bieberich
Feb 16, 2002·Methods : a Companion to Methods in Enzymology·K J Livak, T D Schmittgen
Jun 26, 2002·The Journal of Cell Biology·Akira TsujimuraE Lynette Wilson
Feb 7, 2007·The Journal of Endocrinology·Cíntia Vilanova TeixeiraCristiane da Fonte Ramos
Jul 3, 2007·Molecular Nutrition & Food Research·Retha R NewboldWendy N Jefferson
May 9, 2008·Differentiation; Research in Biological Diversity·Gail S Prins, Oliver Putz
Jun 6, 2008·Endocrine-related Cancer·Gail S Prins
Sep 6, 2008·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Avan Aihie SayerCyrus Cooper
Nov 10, 2009·The Journal of Steroid Biochemistry and Molecular Biology·Stuart J Ellem, Gail P Risbridger
Nov 26, 2009·Asian Journal of Andrology·Cristiane da F RamosFrancisco J B Sampaio
Sep 17, 2010·Genes & Development·Michael M Shen, Cory Abate-Shen
Mar 2, 2011·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·H P PatelA A Sayer
Jan 31, 2012·American Journal of Human Biology : the Official Journal of the Human Biology Council·David J P BarkerJohan G Eriksson
Feb 27, 2013·Life Sciences·Jaqueline C RinaldiSergio L Felisbino
Aug 8, 2013·Reproduction, Fertility, and Development·Cristiane F PinhoWellerson R Scarano
Jan 15, 2014·The Proceedings of the Nutrition Society·Jane L Tarry-Adkins, Susan E Ozanne
Jan 1, 2010·Journal of Developmental Origins of Health and Disease·G S Prins, S-M Ho
May 6, 2016·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Laura S BlekerTessa J Roseboom
Jul 15, 2016·Epigenetics : Official Journal of the DNA Methylation Society·Ana CheongShuk-Mei Ho
Sep 15, 2016·Future Oncology·Matteo FerroOttavio De Cobelli
Oct 4, 2017·The Journal of Clinical Endocrinology and Metabolism·Barbara A CohnPentti K Siiteri

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.