Maternal microchimerism in human fetal tissues

American Journal of Obstetrics and Gynecology
Anna Maria JonssonMagnus Westgren

Abstract

The aim of the present study was to analyze the presence of maternal cells in human fetal tissues in the second trimester. Tissues from 11 second-trimester fetuses terminated because of social reasons or because of malformations and/or trisomy were investigated. By cell sorting and polymerase chain reaction amplification, we studied the presence of maternal CD3+, CD19+, CD34+, and CD45+ in different fetal tissues and in placenta. In the group of fetuses with normal karyotype and normal autopsy findings, 4 of 5 fetuses were positive for maternal microchimerism. In the group in which the fetuses were diagnosed with trisomy 21 and/or malformations, we found cells of maternal origin in 3 of 6 fetuses. The results from this study indicate that maternal microchimerism is a common phenomenon in the second-trimester fetuses. Maternal cells of lymphoid and myeloid lineages and hematopoietic progenitors are widely distributed in the second-trimester fetuses.

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Citations

Feb 14, 2009·Endocrine Pathology·Daniel W Rust, Diana W Bianchi
Sep 14, 2011·PloS One·Hilary S GammillJ Lee Nelson
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Jun 28, 2018·Cell Transplantation·Anna Maria Jonsson KanoldCecilia Götherström
Dec 20, 2012·The Behavioral and Brain Sciences·Evan Charney
Jun 10, 2010·Pediatric Research·Anna Maria JonssonMagnus Westgren
Mar 29, 2019·Scientific Reports·Rianne OpsteltenDerk Amsen
May 17, 2018·Evolution, Medicine, and Public Health·Mel Greaves, William Hughes
May 1, 2020·Current Stem Cell Reports·Martin RodriguezGraҫa Almeida-Porada
Mar 16, 2019·Current Stem Cell Reports·Amir Alhajjat, Aimen Shaaban
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Dec 11, 2020·American Journal of Physical Anthropology·Tiffany D PanDan T A Eisenberg
May 18, 2021·Frontiers in Pediatrics·Bianca CinicolaMarzia Duse

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