PMID: 25733789Mar 4, 2015Paper

Maternal mortality predictors in women with hypertensive disorders of pregnancy: a retrospective cohort study

Ethiopian Journal of Health Sciences
Yifru Berhan, Gezahegn Endeshaw

Abstract

Hypertensive disorders of pregnancy (HDP) are multisystem disorders unique to human pregnancy. They are becoming the leading causes of maternal mortality worldwide, with the majority of deaths occurring in low income countries. However, little is known about the predictors of maternal mortality in women with HDP. A retrospective cohort study was conducted between 2008 and 2013 in three university teaching hospitals among 1015 women admitted with a diagnosis of HDP. Statistically significant associations were assessed by the hazard ratio (HR) with 95% confidence using the Cox proportional hazards model and by the Log Rank test using the Kaplan-Meier survival analyses. There were 51(5%) maternal deaths and the majority died after they developed eclampsia. The median delay in arrival among the deaths was longer than the survivors. The multivariate survival analyses showed an increased risk of maternal mortality among women with eclampsia (HR=8.4), no antenatal care (HR=2.3), being grand multiparous (HR=2.8), having low diastolic blood pressure (HR=4.5), high creatinine level (HR=9.9), use of diazepam as anticonvulsant (HR=2.7) and untreated with antihypertensive drug (HR=4.2). The case fatality rate of HDP was among the highest in...Continue Reading

Citations

Dec 5, 2019·BMC Pregnancy and Childbirth·Amanual Getnet MershaMohammed Assen Seid
Jan 1, 2015·International Scholarly Research Notices·Gezehagn Endeshaw, Yifru Berhan
Nov 19, 2020·Hypertension in Pregnancy : Official Journal of the International Society for the Study of Hypertension in Pregnancy·Gabrijela Brzan SimencMiha Lucovnik

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