PMID: 18400711Apr 11, 2008Paper

Maternal n-3, n-6, and trans fatty acid profile early in pregnancy and term birth weight: a prospective cohort study

The American Journal of Clinical Nutrition
Manon van EijsdenGouke J Bonsel

Abstract

Maternal n-3, n-6, and trans fatty acids are claimed to affect fetal growth, yet evidence is limited. We investigated the association between maternal n-3, n-6, and trans fatty acids measured early in pregnancy and fetal growth. Amsterdam pregnant women (n = 12 373) were invited to complete a questionnaire (response 67%) and donate blood around the 12th pregnancy week for nutrient analysis. For 4336 women, fatty acid concentrations were measured in plasma phospholipids (gas-liquid chromatography). Associations of these concentrations with birth weight and small-for-gestational-age (SGA) risk were analyzed (liveborn singleton term deliveries, n = 3704). Low concentrations of individual n-3 fatty acids and 20:3n-6, the precursor of arachidonic acid (20:4n-6), but high concentrations of the other n-6 fatty acids and the main dietary trans fatty acid (18:1n-9t) were associated with lower birth weight (estimated difference in univariate analysis -52 to -172 g for extreme quintile compared with middle quintile). In general, SGA risk increased accordingly. After adjustment for physiologic, lifestyle-related and sociodemographic factors, low concentrations of most n-3 fatty acids and 20:3n-6 and high concentrations of 20:4n-6 remained ...Continue Reading

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Citations

Dec 2, 2008·European Journal of Epidemiology·Vincent W V Jaddoe
Sep 4, 2010·International Journal of Epidemiology·Manon van EijsdenMarcel F van der Wal
Nov 3, 2010·Reviews on Environmental Health·Sheila Bushkin-Bedient, David O Carpenter
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Jul 29, 2017·Journal of Pediatric Gastroenterology and Nutrition·Emma KjellbergJovanna Dahlgren
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Jun 6, 2009·Paediatric and Perinatal Epidemiology·Jean Golding
May 27, 2014·Nihon eiseigaku zasshi. Japanese journal of hygiene·Yumi HayashiTamie Nakajima
Dec 21, 2019·The American Journal of Clinical Nutrition·Sonia L RobinsonEdwina Yeung
Jan 9, 2020·Journal of Perinatology : Official Journal of the California Perinatal Association·Axelle HogeVincenzo Castronovo
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Nov 6, 2008·The British Journal of Nutrition·Manon van EijsdenGouke J Bonsel
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Jan 29, 2011·The British Journal of Nutrition·Simon J WheelerThomas A B Sanders
Jul 5, 2013·The American Journal of Clinical Nutrition·Tamás Decsi, Günther Boehm

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