Maternal nerve growth factor levels during pregnancy in women with preeclampsia: A longitudinal study

International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience
Vandita D'souzaSadhana Joshi

Abstract

Preeclampsia (PE) is characterized by hypertension and proteinuria. Improper development of the placenta due to altered angiogenesis is the main culprit in PE. Nerve growth factor (NGF) is an angiogenic factor which is expressed and localized in the placenta. Our earlier cross sectional study has shown altered NGF levels at delivery in women with PE. However, there are no studies on NGF levels in PE early in pregnancy before manifestation of the disease. Thus, there is a need to examine the role of NGF in vascular development during different stages of gestation in PE. A longitudinal study was carried out where pregnant women were enrolled from two major hospitals from Pune, Bharati hospital and Gupte hospital. They were followed at three different time points [16-20 weeks (T1), 26-30 weeks (T2) and at delivery (T3)] during pregnancy and maternal blood at every time point and cord blood at delivery was collected and processed. This study included normotensive women (n=88) and women with PE (n=48). NGF levels were measured from maternal and cord plasma using the Emax Immuno Assay System (Promega). The data was analyzed using the SPSS/PC+ package (Version 20.0, Chicago, IL, USA). Maternal NGF levels did not change at all time poi...Continue Reading

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Citations

Jan 25, 2019·International Journal of Endocrinology·David Sánchez-InfantesLourdes Ibáñez
Feb 9, 2021·Frontiers in Veterinary Science·Daniela E BarrazaMartin E Argañaraz
Feb 15, 2020·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Alessio D'AngeloMarisa Patrizia Messina

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