Maternal Nutrient Restriction in Guinea Pigs as an Animal Model for Inducing Fetal Growth Restriction

Reproductive Sciences
Alexander A EliasBryan S Richardson

Abstract

We determined the impact of moderate maternal nutrient restriction (MNR) in guinea pigs on pregnancy outcomes, maternal/fetal growth parameters, and blood analytes to further characterize the utility of this model for inducing fetal growth restriction (FGR). Thirty guinea pig sows were fed ad libitum (Control) or 70% of the control diet prepregnant switching to 90% at midpregnancy (MNR). Animals were necropsied near term with weights obtained on all sows, fetuses, and placenta. Fetal blood sampling and organ dissection were undertaken in appropriate for gestational age (AGA) fetuses from Control litters and FGR fetuses from MNR litters using > or < 80 g which approximated the 10th percentile for the population weight distribution of the Control fetuses. MNR fetal demise rates (1/43) were extremely low in contrast to that seen with uterine artery ligation/ablation models, albeit with increased preterm delivery in MNR sows (3 of 15). We confirm that MNR fetuses are smaller and have increased placental/fetal weight ratios as often seen in human FGR infants. We provide justification for using a fetal weight threshold for categorizing AGA Control and FGR-MNR cohorts reducing population variance, and show that FGR-MNR fetuses have as...Continue Reading

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Citations

Jan 20, 2018·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Catherine L NevinBryan S Richardson
Jul 4, 2018·Pediatric Research·Emily P MasoumyBrian K Stansfield
Mar 19, 2019·Molecular Nutrition & Food Research·Yue-Bang YinYu-Long Yin
Apr 5, 2017·Journal of Animal Science and Biotechnology·Matthias NemethBernard Wallner
Dec 1, 2017·Nutrition Reviews·Daniel J HoffmanDaniel B Hardy
Jul 13, 2018·Frontiers in Physiology·Emily J CammAmanda N Sferruzzi-Perri

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