Maternal O2 transport and fetal growth in Colorado, Peru, and Tibet high-altitude residents

American Journal of Human Biology : the Official Journal of the Human Biology Council
Lorna G Moore

Abstract

Human populations have lived at high altitudes for lengths of time which are likely to be shortest in Colorado, intermediate in Peru, and longest in Tibet. We hypothesized that the longest-resident high-altitude populations have beccome better adapted than shorter-resident groups as a result of superior abilities to transport and/or utilize O2 . Because birth weights are reduced at high altitude and decreased birth weight is associated with increased infant mortality, our criterion for assessing adaptation was preservation of birth weights close to values associated with the lowest mortality risk. Colorado (3,100 m) and Peru (4,300 m) birth weights averaged 3,186±70 g and 2,920±90 g respectively. A sample of 15 births from Tibet (3,658 m) weighed 3,307±110 g which was more than their altitude counterparts and close to sea-level norms. Pregnancy increased maternal ventilation at all three study sites. In Peru, the resultant elevation in arterial O2 saturation offset the pregnancy-induced fall in hemoglobin concentration to preserve arterial O2 content at nonpregnant levels. Arterial O2 content decreased slightly in Colorado and more markedly in Tibet in the pregnant compared to the nonpregnant state. The Colorado and Peru women ...Continue Reading

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Citations

Apr 16, 1998·American Journal of Physical Anthropology·L S CurranL G Moore
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