Maternal obesity and gestational diabetes: Impact on arterial wall layer thickness and stiffness in early childhood - RADIEL study six-year follow-up

Atherosclerosis
Johnny K M SundholmTaisto Sarkola

Abstract

Gestational diabetes (GDM) and maternal obesity are linked to weight gain in childhood and an increased risk of cardiovascular disease later in life. We assessed the effects of GDM and maternal obesity on arterial function and morphology in relation to body anthropometrics and composition in early childhood. We assessed body size and composition, blood pressure (BP), arterial morphology and stiffness in 201 pairs of obese mothers (pre-pregnancy BMI 30.7 ± 5.6 kg/m2, 96 with GDM) and their children at 6.1 years (SD 0.5). Child BMI (z-score 0.45 ± 0.92; p < 0.001) and common carotid intima-media thickness (IMT, z-score 0.15 ± 0.75, p = 0.003) were increased compared with a healthy Finnish reference population. No associations with maternal GDM was found. Carotid IMT and pulse wave velocity were unrelated to child sex, anthropometrics, body composition, BP, as well as maternal anthropometrics and body composition. Carotid stiffness was independently predicted by second trimester fasting glucose. Child lean body mass was the strongest independent predictor for radial (RA), and brachial artery (BA) lumen diameter (LD) and BA IMT (LD: RA: r2 = 0.068, p < 0.001; BA: r2 = 0.108, p < 0.001; IMT: BA: r2 = 0.161, p < 0.001) and carotid LD...Continue Reading

Citations

Jul 10, 2020·Prenatal Diagnosis·Sezen KislalAndrea G Edlow
Sep 19, 2020·European Journal of Pediatrics·Luisa SemmlerRenate Oberhoffer-Fritz
Jul 30, 2020·Canadian Association of Radiologists Journal = Journal L'Association Canadienne Des Radiologistes·Rossana IzzettiMario Gabriele
Feb 28, 2021·International Journal of Obesity : Journal of the International Association for the Study of Obesity·Cyrielle PayenCéline Fassot
Jul 22, 2021·Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy·Linda LitwinTaisto Sarkola
Jan 16, 2022·BMC Pediatrics·Rasmus F W OlanderTaisto Sarkola

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