Maternal Obesity During Pregnancy and Lactation Influences Offspring Obesogenic Adipogenesis but Not Developmental Adipogenesis in Mice.

Nutrients
Dyan SellayahF R Cagampang

Abstract

Obesity is an escalating health crisis of pandemic proportions and by all accounts it has yet to reach its peak. Growing evidence suggests that obesity may have its origins in utero. Recent studies have shown that maternal obesity during pregnancy may promote adipogenesis in offspring. However, these studies were largely based on cell culture models. Whether or not maternal obesity impacts on offspring adipogenesis in vivo remains to be fully established. Furthermore, in vivo adipogenic differentiation has been shown to happen at distinct time periods, one during development (developmental adipogenesis-which is complete by 4 weeks of age in mice) and another in adulthood in response to feeding a high-fat (HF) diet (obesogenic adipogenesis). We therefore set out to determine whether maternal obesity impacted on offspring adipocyte hyperplasia in vivo and whether maternal obesity impacted on developmental or obesogenic adipogenesis, or both. Our findings reveal that maternal obesity is associated with enhanced obesogenic adipogenesis in HF-fed offspring. Interestingly, in newly weaned (4-week-old) offspring, maternal obesity is associated with adipocyte hypertrophy, but there were no changes in adipocyte number. Our results sugge...Continue Reading

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Citations

Jul 31, 2019·American Journal of Physiology. Endocrinology and Metabolism·Tomás CerdóCristina Campoy
Dec 4, 2021·Journal of Developmental Origins of Health and Disease·Carolina M SaulloDébora C Damasceno
Jan 9, 2022·International Journal of Obesity : Journal of the International Association for the Study of Obesity·Christina SavvaMarion Korach-André

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Methods Mentioned

BETA
PCR

Software Mentioned

NRecon
VGStudio Max

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