Abstract
Obesity is an escalating health crisis of pandemic proportions and by all accounts it has yet to reach its peak. Growing evidence suggests that obesity may have its origins in utero. Recent studies have shown that maternal obesity during pregnancy may promote adipogenesis in offspring. However, these studies were largely based on cell culture models. Whether or not maternal obesity impacts on offspring adipogenesis in vivo remains to be fully established. Furthermore, in vivo adipogenic differentiation has been shown to happen at distinct time periods, one during development (developmental adipogenesis-which is complete by 4 weeks of age in mice) and another in adulthood in response to feeding a high-fat (HF) diet (obesogenic adipogenesis). We therefore set out to determine whether maternal obesity impacted on offspring adipocyte hyperplasia in vivo and whether maternal obesity impacted on developmental or obesogenic adipogenesis, or both. Our findings reveal that maternal obesity is associated with enhanced obesogenic adipogenesis in HF-fed offspring. Interestingly, in newly weaned (4-week-old) offspring, maternal obesity is associated with adipocyte hypertrophy, but there were no changes in adipocyte number. Our results sugge...Continue Reading
References
Jan 2, 2001·Endocrine Reviews·B L Wajchenberg
Oct 10, 2009·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Kimberley D BruceChristopher D Byrne
Aug 3, 2011·Journal of Cell Science·Christopher E LoweJustin J Rochford
Sep 9, 2011·American Journal of Physiology. Endocrinology and Metabolism·Stephanie M KrasnowDaniel L Marks
Feb 4, 2012·Frontiers in Genetics·Maria Z Alfaradhi, Susan E Ozanne
Feb 14, 2012·Cell Metabolism·Rana K GuptaBruce M Spiegelman
Jul 23, 2013·Biochimica Et Biophysica Acta·Lyda WilliamsMaureen J Charron
Jul 26, 2013·Diabetes·Qi-Yuan YangMin Du
Aug 21, 2013·Endocrinology·Sarah J BorengasserKartik Shankar
Sep 3, 2013·Nature Medicine·Qiong A WangPhilipp E Scherer
Oct 9, 2013·Nature Medicine·Matthew Harms, Patrick Seale
Nov 19, 2013·Cell Metabolism·Ryan BerryMatthew S Rodeheffer
Mar 19, 2014·American Journal of Obstetrics and Gynecology·Mina DesaiMichael G Ross
Jun 2, 2014·Lancet·Marie NgEmmanuela Gakidou
Dec 2, 2014·Cell Reports·Yuwei JiangJonathan M Graff
Mar 3, 2015·Nature Cell Biology·Elise JefferyMatthew S Rodeheffer
Mar 31, 2015·Cell·Oliver J Rando, Rebecca A Simmons
Apr 16, 2015·PloS One·Nathan M LongStephen P Ford
Apr 18, 2015·Nature Communications·Myrte MerkesteinRoger D Cox
Aug 19, 2015·Nature Cell Biology·Qiong A WangPhilipp E Scherer
Dec 4, 2015·Diabetes·Kristen E BoyleJacob E Friedman
Apr 10, 2016·The Journal of Physiology·Xingwei LiangMin Du
Apr 29, 2016·The Journal of Endocrinology·Simon LecoutreChristophe Breton
May 6, 2016·Frontiers in Endocrinology·Sung Sik ChoeJae Bum Kim
Jun 6, 2016·Trends in Endocrinology and Metabolism : TEM·Daniel C BerryJonathan M Graff
Jun 1, 2017·Obesity Facts·Gijs H Goossens
Citations
Jul 31, 2019·American Journal of Physiology. Endocrinology and Metabolism·Tomás CerdóCristina Campoy
Nov 2, 2019·International Journal of Molecular Sciences·Jane K ClealFelino R Cagampang
Jan 18, 2020·Nutrients·Hunter W KorsmoXinyin Jiang
Dec 4, 2021·Journal of Developmental Origins of Health and Disease·Carolina M SaulloDébora C Damasceno
Jan 9, 2022·International Journal of Obesity : Journal of the International Association for the Study of Obesity·Christina SavvaMarion Korach-André