Maternal obesity enhances collagen accumulation and cross-linking in skeletal muscle of ovine offspring.

PloS One
Yan HuangMin Du

Abstract

Maternal obesity (MO) has harmful effects on both fetal development and subsequent offspring health. We previously demonstrated that MO enhances collagen accumulation in fetal skeletal muscle, but its impact on mature offspring muscle collagen accumulation is unknown. Ewes were fed either a control diet (Con, fed 100% of NRC nutrient recommendations) or obesogenic diet (OB, fed 150% of NRC nutrient recommendations) from 60 days before conception to birth. All ewes received the Con diet during lactation. Male offspring were euthanized at 2.5 years (mean) and the left Longissimus dorsi (LD) muscle and semitendinosus (ST) muscle were sampled. Collagen concentration increased by 37.8 ± 19.0% (P<0.05) in LD and 31.2 ± 16.0% (P<0.05) in ST muscle of OB compared to Con offspring muscle. Mature collagen cross-linking (pyridinoline concentration) was increased for 22.3 ± 7.4% and 36.3 ± 9.9% (P<0.05) in LD and ST muscle of OB group respectively. Expression of lysyl oxidase, lysyl hydroxylase-2b (LH2b) and prolyl 4-hydroxylase (P4HA) was higher in OB LD and ST muscle. In addition, the expression of metalloproteinases (MMPs) was lower but tissue inhibitor of metalloproteinases (TIMPs) was higher in OB offspring muscle, indicating reduced ...Continue Reading

References

Apr 1, 1992·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·K ReiserR B Rucker
Aug 1, 1992·American Journal of Respiratory Cell and Molecular Biology·G Murphy, A J Docherty
Dec 15, 1986·The Biochemical Journal·S E WhithamA J Docherty
Apr 1, 1988·Calcified Tissue International·J J Wu, D R Eyre
Jan 1, 1986·Toxicology Letters·B A MyersR B Rucker
Jan 1, 1985·Research in Experimental Medicine. Zeitschrift Für Die Gesamte Experimentelle Medizin Einschliesslich Experimenteller Chirurgie·M LehtoA J Bailey
Jan 1, 1984·Annual Review of Biochemistry·D R EyreP M Gallop
Mar 1, 1981·Archives of Neurology·M FoidartW K Engel
Jan 1, 1996·Connective Tissue Research·S G VellemanR J McCormick
Apr 3, 1998·Matrix Biology : Journal of the International Society for Matrix Biology·L I Smith-Mungo, H M Kagan
Feb 15, 2001·Canadian Journal of Applied Physiology = Revue Canadienne De Physiologie Appliquée·R C LeeS B Heymsfield
Sep 15, 2001·American Journal of Physiology. Heart and Circulatory Physiology·S D ZimmermanR J McCormick
Oct 20, 2001·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·T A MillerM D Delp
Dec 17, 2002·Diabetes Research and Clinical Practice·Daniel A MartinezArthur C Vailas
Sep 11, 2003·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Hobe J Schröder
Sep 27, 2003·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Fukiko FurukawaKyoichi Inoue
Nov 25, 2003·The Journal of Investigative Dermatology·Nanjun WuJeffrey M Davidson
Dec 5, 2003·Journal of Hypertension·Muzahir H TayebjeeGregory Y Lip
Dec 1, 2004·Aging Cell·Marjorie L BeggsCharlotte A Peterson
Dec 22, 2005·Journal of Anatomy·J F KarunaratneN C Stickland
Feb 6, 2007·Biochemical and Biophysical Research Communications·Magdalena DziembowskaBozena Kaminska
Aug 21, 2007·Current Drug Targets·Brigitte ReusensClaude Remacle
Feb 26, 2008·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Betty R Vohr, Charlotte M Boney
Dec 17, 2008·PloS One·Charlotte LahouteDominique Daegelen
Dec 23, 2008·European Journal of Nutrition·Stéphanie A BayolNeil C Stickland
Jan 30, 2009·American Journal of Physiology. Endocrinology and Metabolism·Jun F TongMin Du
Jun 24, 2009·Molecular and Cellular Biology·Nils HalbergPhilipp E Scherer
Jul 14, 2009·American Journal of Physiology. Heart and Circulatory Physiology·Sherma ZibadiRonald R Watson

❮ Previous
Next ❯

Citations

Oct 30, 2013·Nutrition Reviews·Peter W NathanielszElena Zambrano
Oct 10, 2014·Journal of Developmental Origins of Health and Disease·S A BayolG D Wadley
Sep 10, 2015·Animal : an International Journal of Animal Bioscience·Z G MiaoM Du
May 9, 2015·Meat Science·Min DuMei-Jun Zhu
Jun 18, 2016·International Journal of Environmental Research and Public Health·Pascale Chavatte-PalmerDelphine Rousseau-Ralliard
Oct 1, 2016·Journal of Developmental Origins of Health and Disease·H DickinsonJ L Morrison
Sep 24, 2014·Journal of Animal Science and Biotechnology·Sarah A ReedKristen E Govoni
Oct 5, 2019·Animal : an International Journal of Animal Bioscience·X LiM Du
Aug 25, 2020·Maternal and Child Health Journal·Samantha M McDonaldLinda E May
Sep 26, 2020·International Journal of Environmental Research and Public Health·John F OdhiamboStephen P Ford
Sep 22, 2020·American Journal of Physiology. Endocrinology and Metabolism·Jasmine MikovicSéverine Lamon
Feb 28, 2021·International Journal of Obesity : Journal of the International Association for the Study of Obesity·Cyrielle PayenCéline Fassot

❮ Previous
Next ❯

Methods Mentioned

BETA
deamination
Infrared Imaging
PCR

Software Mentioned

SAS

Related Concepts

Related Feeds

Cardiovascular Diseases: Risk Factors

Cardiovascular disease is a significant health concern. Risk factors include hypertension, obesity, dyslipidemia and smoking. Women who are postmenopausal are at an increased risk of heart disease. Here is the latest research for risk factors of cardiovascular disease.

Cardiovascular Inflammation

Inflammation plays a significant role in the development of cardiovascular diseases, an understanding of these endogenous processes is critical for evaluating the risks and potential treatment strategies. Discover the latest research on cardiovascular inflammation here.

CV Disorders & Type 2 Diabetes

This feed focuses on the association of cardiovascular diseases in patients with type 2 diabetes.