Maternal obesity is not associated with placental lipid accumulation in women with high omega-3 fatty acid levels.

Placenta
Fernanda L AlvaradoPerrie O'Tierney-Ginn

Abstract

Placentas of obese women have higher lipid content compared to lean women. We have previously shown that supplementation of overweight and obese women with omega-3 fatty acids decreases placental esterification pathways and total lipid content in a mid-western population (Ohio). We hypothesized that placental lipid accumulation and inflammation would be similar between lean and obese women living in a region of high omega-3 intake, such as Hawaii. Fifty-five healthy, normal glucose tolerant women from Honolulu Hawaii, dichotomized based on pre-pregnancy BMI into lean (BMI <25 kg/m2, n = 29) and obese (BMI >30 kg/m2, n = 26), were recruited at scheduled term cesarean delivery. Maternal plasma DHA levels were analyzed by mass spectrometry. Expression of key genes involved in fatty acid oxidation and esterification were measured in placental tissue using qPCR. Total lipids were extracted from placental tissue via the Folch method. TNF-α concentration was measured by enzyme-linked immunosorbent assay in placental lysates. DHA levels were higher in lean women compared to obese women (P = 0.02). However, DHA levels in obese women in Hawaii were eight times higher compared to obese Ohioan women (P=<0.0001). Placental lipid content and...Continue Reading

Citations

Jan 26, 2021·Clinical Therapeutics·Alison J EastmanDavid M Aronoff
Dec 29, 2020·Clinical Therapeutics·Aisha RasoolPerrie O'Tierney-Ginn
Apr 23, 2021·PloS One·Sathish Kumar NatarajanAnn Anderson-Berry
Apr 24, 2021·Brain and Neuroscience Advances·Jonathan Davis, Erik Mire

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