Maternal obesity results in decreased syncytiotrophoblast synthesis of palmitoleic acid, a fatty acid with anti-inflammatory and insulin-sensitizing properties

FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology
Véronique Ferchaud-RoucherTheresa L Powell

Abstract

The fetus is dependent on delivery of fatty acids (FAs) by the syncytiotrophoblast, the transporting epithelium of the human placenta. Obese pregnant women have dyslipidemia; however, whether obesity impacts placental lipid transport and metabolism remains to be fully established. Palmitoleic acid (POA), an FA with anti-inflammatory and insulin-sensitizing properties, is synthesized from palmitic acid (PA) catalyzed by stearoyl-coenzyme A desaturase (SCD) activity. We hypothesized that the uptake and incorporation of FAs and POA synthesis are reduced in primary human trophoblasts (PHTs) isolated from pregnancies complicated by maternal obesity. Villous cytotrophoblasts were isolated from 7 placentas of obese [body mass index (BMI) = 37.5 ± 1.9] and 12 normal (BMI = 23.6 ± 0.6) mothers. FA uptake and incorporation were assessed using uniformly labeled (U[13C])-FA mixtures of PA, oleic acid (OA), linoleic acid, and docosahexaenoic acid. Cellular [13C] FAs were quantified both in total cellular lipids and in lipid classes by GC-MS. Uptake and incorporation of [13C] FAs in total cellular lipids were not different in PHTs isolated from obese mothers compared with normal mothers. Only the concentration of OA was increased in the trig...Continue Reading

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Citations

Nov 11, 2020·Reproductive Sciences·Alejandra Abascal-SaizJosé L Bartha
Dec 16, 2020·Biochimica Et Biophysica Acta. Molecular and Cell Biology of Lipids·Theresa L PowellVéronique Ferchaud-Roucher
Dec 23, 2020·International Journal of Molecular Sciences·Małgorzata SzczukoMaciej Ziętek
Apr 23, 2021·PloS One·Sathish Kumar NatarajanAnn Anderson-Berry
May 14, 2020·Current Vascular Pharmacology·A L FowdenA N Sferruzzi-Perri

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