Maternal omega 3 fatty acid supplementation during pregnancy to a micronutrient-imbalanced diet protects postnatal reduction of brain neurotrophins in the rat offspring

Neuroscience
Pratiksha SableSadhana R Joshi

Abstract

An altered one carbon cycle (folic acid, vitamin B(12)) and omega 3 fatty acid metabolism during pregnancy can increase the risk for neurodevelopmental disorders in the offspring. Our earlier studies have shown that a maternal diet imbalanced with micronutrients like folic acid, vitamin B(12) reduces levels of brain docosahexaenoic acid (DHA) and neurotrophins in the offspring at birth. The present study examines whether these effects can be reversed by a postnatal diet. Pregnant female rats were divided into six treatment groups at two levels of folic acid both in the presence and absence of vitamin B(12). Omega 3 fatty acid supplementation was given to the vitamin B(12)-deficient groups. Following delivery, eight dams from each group were randomly shifted back to control and remaining eight continued on the same treatment diet. Plasma homocysteine levels could be normalized by a postnatal control diet. Brain DHA levels were similar in all the groups irrespective of the diet consumed during lactation. Brain-derived nerve growth factor (BDNF) and nerve growth factor (NGF) levels were lower in both the vitamin B(12)-deficient groups even after consuming a diet with normal levels of vitamin B(12) during lactation (p<0.05 for all)...Continue Reading

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Citations

Jan 28, 2014·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Pratiksha SableSadhana Joshi
Jan 27, 2016·Journal of Biomedical Science·Richa RathodSadhana Joshi
Jan 23, 2013·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Kamini DangatSadhana Joshi
Jan 22, 2013·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Nisha S WadhwaniSadhana R Joshi
Nov 22, 2013·Nutritional Neuroscience·Pratiksha SableSadhana Joshi
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May 25, 2015·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Amrita KhaireSadhana Joshi
Apr 19, 2015·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Richa S RathodSadhana R Joshi
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