Maternal oxygen administration and fetal cerebral oxygenation: studies on near-term fetal lambs at both low and high altitude

American Journal of Obstetrics and Gynecology
Takuji TomimatsuLawrence D Longo

Abstract

We tested the hypothesis that O2 administration to the mother would increase arterial O2 tension (PaO2) and cortical tissue O2 tension (tPO2) in both the normoxic control fetus and that acclimatized to high altitude, and that this effect might be greater in the high altitude fetus than that at sea level. Pregnant ewes were divided into either low-altitude group or high-altitude group (3820 m; maintained from day 30 of gestation to near-term, term = 145 days; n = 6 each). In near-term fetuses we instrumented the cerebral cortex with tissue PO2-laser Doppler flow probes, and placed arterial catheters. With the ewe breathing either air or 50% O2, we measured fetal arterial and brain tissue PO2 and cerebral blood flow (CBF). In response to maternal O2 administration, in both low- and high-altitude fetuses, PaO2, O2 content, and brain tissue PO2 increased significantly. Nonetheless, the fetuses at high altitude showed significantly greater increase in both PaO2 and cerebral tPO2, than that seen in fetuses at low altitude. In neither group was there a change in CBF or cerebral metabolic rate for O2. Maternal O2 administration significantly increased PaO2 and cerebral tPO2 of the fetus both at low altitude and at high altitude, with t...Continue Reading

References

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Citations

Oct 27, 2006·Pediatric Research·Takuji TomimatsuLawrence D Longo
Jul 7, 2012·The Journal of Obstetrics and Gynaecology Research·Takuji TomimatsuTadashi Kimura
Sep 23, 2009·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·A SørensenN Uldbjerg
Dec 21, 2013·Journal of Magnetic Resonance Imaging : JMRI·Bjoern P SchoennagelUlrike Wedegaertner
Apr 4, 2007·American Journal of Obstetrics and Gynecology·Takuji TomimatsuLawrence D Longo
Jul 20, 2007·Reproductive Sciences·Takuji TomimatsuLawrence D Longo
Oct 26, 2007·Reproductive Sciences·Takuji TomimatsuLawrence D Longo
May 5, 2012·Reproductive Sciences·Takuji TomimatsuTadashi Kimura
Jan 20, 2015·American Journal of Physiology. Heart and Circulatory Physiology·Xiaoxiao TaoDavid A Hessinger

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