PMID: 9170475Jun 1, 1997Paper

Maternal oxygen desaturation with intravenous magnesium therapy

Obstetrics and Gynecology
J A ThorpM Poskin

Abstract

To describe the occurrence, treatment, and outcome of maternal oxygen desaturation during magnesium sulfate therapy. A post hoc analysis of a randomized double-blind trial, designed to determine if mothers at risk for premature delivery treated with phenobarbital and vitamin K had less frequent intracranial hemorrhage in their newborns, was done. A subset of these patients at imminent risk for delivery received both intravenous magnesium sulfate and intravenous study drug (phenobarbital or placebo) and was monitored with maternal oxygen saturation monitoring. One hundred one women (29%) in the trial had pulse oximetry; 47 were assigned to placebo and 54 to the treatment group. The placebo and treatment groups had the following similarities: mean lowest oxygen saturation by pulse oximeter (93.4% +/- 3.0 compared with 93.1% +/- 3.3). mean highest magnesium levels (6.3 mEq/L +/- 1.5 compared with 6.2 mEq/L +/- 0.9), frequencies of desaturation events defined as oxygen saturation below 90% (11% compared with 11%), gestational age at delivery, birth weight, Apgar scores, and cord arterial pH. Using regression analysis, multiple gestation was the only one of 14 independent variables associated with low maternal oxygen saturation. Pre...Continue Reading

References

Oct 1, 1993·Current Opinion in Obstetrics & Gynecology·L Gilbertson, S Datta

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Citations

Feb 1, 2003·Clinical Physiology and Functional Imaging·Jouko P PirhonenKarel Marsal
Jan 22, 2010·The Cochrane Database of Systematic Reviews·Caroline A CrowtherDavid J Henderson-Smart

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