Maternal para-chlorophenylalanine exposure modifies central monoamines and behaviors in the adult offspring

Brain Research
Ludmila A VataevaVladimir A Otellin

Abstract

We reported a perspective animal model of neurodevelopmental disorders using rats prenatally exposed to an inhibitor of serotonin (5HT) synthesis, para-chlorophenylalanine (PCPA). Earlier, we demonstrated that prenatal exposure to PCPA caused fetal 5HT depletion and changes both in open field activity and in depression-related behavior, as well as impairments in spatial learning in the adult offspring (Vataeva et al., 2007). The present study revealed that prenatal PCPA treatment resulted in the offspring's significantly reduced anxiety-related behavior in the elevated plus-maze and reduced neophobia to intake fluids in a novel environment. These effects are accompanied by hedonic changes in the form of an appropriate increase in saccharin preference. We confirmed our earlier finding that prenatal PCPA exposure affected the open field locomotor activity. In the present study we have shown that the selective 5HT reuptake inhibitor (SSRI) paroxetine decreases locomotor activity in the prenatally PCPA-treated offspring. It was also found that in the PCPA-treated fetal brain, 5HT depletion was associated with a significant decrease in the level of dopamine (DA) metabolite dihydroxyphenylacetic acid (DOPAC) and with a reduction of D...Continue Reading

References

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Jul 26, 2007·The European Journal of Neuroscience·Tania VitalisJohn G Parnavelas
Aug 19, 2007·Brain Research·Ludmila A VataevaVladimir A Otellin
Oct 30, 2007·Journal of Pharmacological Sciences·Shigeo MiyataJunzo Kamei
Jan 25, 2008·The European Journal of Neuroscience·Simone M SmitsMarten P Smidt

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Citations

Jul 2, 2009·European Archives of Psychiatry and Clinical Neuroscience·Didier Jutras-AswadYasmin L Hurd
Jul 27, 2012·Translational Psychiatry·V MosienkoN Alenina
Jan 11, 2011·Interdisciplinary Toxicology·Michal Dubovický
Mar 2, 2010·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Shravani Bhanja, Kochupurackal P Mohanakumar
Mar 10, 2010·Brain Research·María Carmen Fernández-GalazLuis M Garcia-Segura
Nov 30, 2019·Environmental Epigenetics·Nicole M WannerChristopher Faulk

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