Maternal parity and its effect on adipose tissue deposition and endocrine sensitivity in the postnatal sheep.

The Journal of Endocrinology
Melanie A HyattM E Symonds

Abstract

Maternal parity influences size at birth, postnatal growth and body composition with firstborn infants being more likely to be smaller with increased fat mass, suggesting that adiposity is set in early life. The precise effect of parity on fat mass and its endocrine sensitivity remains unclear and was, therefore, investigated in the present study. We utilised an established sheep model in which perirenal-abdominal fat mass (the major fat depot in the neonatal sheep) increases approximately 10-fold over the first month of life and focussed on the impact of parity on glucocorticoid sensitivity and adipokine expression in the adipocyte. Twin-bearing sheep of similar body weight and adiposity that consumed identical diets were utilised, and maternal blood samples were taken at 130 days of gestation. One offspring from each twin pair was sampled at 1 day of age, coincident with the time of maximal recruitment of uncoupling protein 1 (UCP1), whilst its sibling was sampled at 1 month, when UCP1 had disappeared. Plasma leptin was lower in nulliparous mothers than in multiparous mothers, and offspring of nulliparous mothers possessed more adipose tissue with increased mRNA abundance of leptin, glucocorticoid receptor and UCP2, adaptatio...Continue Reading

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Citations

Jul 1, 2010·Animal : an International Journal of Animal Bioscience·M E SymondsH Budge
Mar 10, 2012·Diabetologia·M E SymondsH Budge
Feb 24, 2012·Journal of Applied Genetics·Ya-Nan YuanJian-Liang Wu
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Dec 19, 2014·BMC Public Health·Kumari M RathnayakeV P Wickramasighe
May 14, 2016·Theriogenology·M E SymondsH Budge
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May 29, 2014·Hypertension·Romy GaillardVincent W V Jaddoe
Oct 26, 2021·Journal of Perinatal Medicine·Lars BrodowskiManfred Voigt

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Methods Mentioned

BETA
dissection
ELISA
PCR
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Software Mentioned

SPSS

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