Maternal-placental interactions of oxidative stress and antioxidants in preeclampsia

Seminars in Reproductive Endocrinology
S W Walsh

Abstract

This review addresses the general hypothesis that the pathogenesis of preeclampsia is related to an imbalance of increased oxidative stress and lipid peroxidation coupled to a deficiency of antioxidant protection. Evidence will be presented that this imbalance is present in both the maternal compartment and the placental compartment and that interactions between these two compartments result in the clinical manifestations of this disorder. We suggest the following as a scenario for the development of preeclampsia: Oxidative stress in the maternal compartment affects the placenta in such a way as to bring about a decrease in placental antioxidant enzyme protection. The oxidative stress in the maternal compartment may be preexisting (e.g., obesity, diabetes, hyperlipidemia) or may be caused by placental secretion of lipid peroxides. Decreased placental antioxidant enzyme protection leads to a cascade of events in the placenta of uncontrolled lipid peroxidation with increased thromboxane production and increased tumor necrosis factor (TNF-alpha) production. Increased placental secretion of lipid peroxides and/or TNF-alpha results in activation of leukocytes as they circulate through the intervillous space. The activated leukocytes...Continue Reading

Citations

Dec 23, 2008·Archives of Gynecology and Obstetrics·Yan-Qiong OuyangHui-Zhen Chen
Feb 2, 2013·Journal of Obstetrics and Gynaecology of India·Brahmarshi DasHarendra Nath Das
Mar 23, 2004·Placenta·L Poston, M T M Raijmakers
Dec 20, 2003·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Scott W Walsh
Mar 22, 2001·Journal of Psychosomatic Research·J M SikkemaA Franx
Feb 13, 2001·Obstetrics and Gynecology·M T RaijmakersW H Peters
Sep 1, 2001·Obstetrics and Gynecology·P R PalanS L Romney
Oct 18, 2002·Obstetrics and Gynecology·Scott KaumaThomas Peng
Nov 27, 1999·Obstetrics and Gynecology·P L ZusterzeelE A Steegers
Nov 24, 1999·Reproductive Toxicology·R E Little, B C Gladen
Oct 4, 2002·Nutrition·T P Stein
Sep 29, 2001·Gynécologie, obstétrique & fertilité·C W Redman, I L Sargent
Mar 10, 2010·The British Journal of Nutrition·Corinna FrankeBerthold Koletzko
Jan 10, 2004·Antioxidants & Redox Signaling·Phyllis A Dennery
Jan 15, 2002·Journal of Women's Health & Gender-based Medicine·S Yeo, S T Davidge
May 18, 2006·Annual Review of Nutrition·Janet C King
Sep 29, 2011·Hypertension·Nikita MishraScott W Walsh
Oct 13, 2009·Reproductive Sciences·Tanvi J ShahScott W Walsh
Mar 12, 2010·Reproductive Sciences·Teddi BachawatyScott W Walsh
May 14, 2008·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Hiroo SatohMotohiro Takeya
Jun 17, 2014·Laboratory Investigation; a Journal of Technical Methods and Pathology·Arjun JainChristiane Albrecht
Mar 2, 2013·Journal of Perinatology : Official Journal of the California Perinatal Association·M R ParrishW L May
Mar 8, 2006·Archives of Gynecology and Obstetrics·Chunfang QiuMichelle A Williams
Nov 16, 2010·Archives of Gynecology and Obstetrics·Ana Bertha Zavalza-Gómez
Feb 24, 2001·Free Radical Research·P L ZusterzeelE A Steegers
Jun 13, 2015·International Journal of Molecular Sciences·Piotr ZabulNarcyz Knap
Mar 10, 2016·Pregnancy Hypertension·Salih SerinHakan Kıran
Mar 1, 2012·Journal of the Formosan Medical Association = Taiwan Yi Zhi·Yu-Chieh ChenLi-Tung Huang
Oct 17, 2015·The British Journal of Dermatology·R B SteeleA G Ortega-Loayza
Jan 22, 2005·Seminars in Nephrology·Chun LamS Ananth Karumanchi
May 21, 2008·Journal of Reproductive Immunology·Jessica G DrenzekThaddeus G Golos

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