Maternal plasma lipid concentrations in early pregnancy and risk of preeclampsia

American Journal of Hypertension
Daniel A EnquobahrieDavid A Luthy

Abstract

We investigated the relationship between early pregnancy plasma lipid concentrations and risk of preeclampsia. In a prospective cohort study, maternal blood samples were collected at an average of 13 weeks gestation. From the cohort, we selected 57 women who developed preeclampsia and 510 who remained normotensive and served as control subjects. Plasma lipid concentrations were measured enzymatically by standardized assays. Logistic regression procedures were used to calculate adjusted odds ratios (OR) and 95% confidence intervals (CI). Women who subsequently developed preeclampsia had 10.4%, 13.6%, and 15.5% higher concentrations of LDL cholesterol, triglycerides, and LDL/HDL ratios, respectively, than did control subjects (P <.05). The HDL cholesterol concentrations were 7.0% lower in women with preeclampsia than in control subjects (P <.05). After adjustment, there was a 3.60-fold increase in risk of preeclampsia among women with total cholesterol >205 mg/dL (95% CI 1.23 to 10.51) and a 4.15-fold increase in the risk of preeclampsia among women with triglyceride levels >133 mg/dL (95% CI 1.50 to 11.49). A linear increase in preeclampsia risk was observed with increasing tertiles of LDL cholesterol, triglyceride concentration...Continue Reading

Citations

Sep 1, 2006·Indian Journal of Clinical Biochemistry : IJCB·Jayanta DePradip Kumar Saha
Mar 29, 2008·Metabolic Syndrome and Related Disorders·Pathmaja Paramsothy, Robert H Knopp
Dec 8, 2009·Human Reproduction Update·Scott M NelsonLucilla Poston
Dec 12, 2012·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Malou P H SchreursMarilyn J Cipolla
Mar 23, 2012·The Journal of Clinical Endocrinology and Metabolism·Arpita BasuTimothy J Lyons
Feb 8, 2013·International Journal of Molecular Sciences·Xiao HuangChristiane Albrecht
Feb 5, 2013·North American Journal of Medical Sciences·Madhusudan DeyReema Kumar
May 7, 2014·Biomarkers in Medicine·Melanie Griffin, Andrew H Shennan
Jul 6, 2014·American Journal of Epidemiology·Cassandra N SpracklenKelli K Ryckman
Jan 21, 2012·ISRN Obstetrics and Gynecology·Dejene F AbetewMichelle A Williams
May 29, 2008·Hypertension in Pregnancy : Official Journal of the International Society for the Study of Hypertension in Pregnancy·SeonAe YeoSharon O'Leary
Feb 2, 2016·Hypertension in Pregnancy : Official Journal of the International Society for the Study of Hypertension in Pregnancy·Nabih I El KhoulyEman E Badr
Jan 14, 2011·Archives of Physiology and Biochemistry·B H KandimallaS S Maiya
Mar 24, 2006·BJOG : an International Journal of Obstetrics and Gynaecology·J G RayC M Bell
Jun 29, 2015·Human Reproduction Update·Stefano PalombaBart C J M Fauser
Aug 15, 2014·Hypertension in Pregnancy : Official Journal of the International Society for the Study of Hypertension in Pregnancy·Helen L BarrettLeonie K Callaway
Sep 10, 2014·Frontiers in Physiology·Lesia O KurlakFiona Broughton Pipkin
Jul 19, 2008·American Journal of Hypertension·Chunfang QiuMichelle A Williams
May 30, 2009·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Sindhu K SrinivasMichal A Elovitz
Jan 5, 2008·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Tinnakorn ChaiworapongsaSonia Hassan
Jan 30, 2015·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·A A Baschat
Jun 17, 2011·The Journal of Obstetrics and Gynaecology Research·Oya DemirciSadiye Eren
May 27, 2008·Journal de gynécologie, obstétrique et biologie de la reproduction·P MervielJ Gondry
Dec 11, 2007·Hypertension in Pregnancy : Official Journal of the International Society for the Study of Hypertension in Pregnancy·Mayi Mayret-MesquitiNoé Alvarado-Vasquez
Nov 23, 2012·Reproductive Sciences·Malou P H Schreurs, Marilyn J Cipolla
Oct 30, 2016·Obesity Research & Clinical Practice·Daniel A EnquobahrieMichelle A Williams
Oct 28, 2016·Journal of Perinatology : Official Journal of the California Perinatal Association·C WangH Yang
Sep 15, 2010·Hypertension·Louise C KennyUNKNOWN Screening for Pregnancy Endpoints Consortium
Sep 26, 2015·Arteriosclerosis, Thrombosis, and Vascular Biology·Line H TangeråsAnn-Charlotte Iversen
Jun 23, 2010·Obstetrics and Gynecology·Anjel VahratianDawn P Misra
May 5, 2006·Medicine and Science in Sports and Exercise
Jun 7, 2006·Epidemiology·Ihunnaya O FrederickMichelle A Williams
Mar 6, 2019·Archives of Gynecology and Obstetrics·Qi WuDanqing Chen
Nov 16, 2005·Medicine and Science in Sports and Exercise·Carole B RudraTanya K Sorensen
Dec 1, 2005·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Daniel A EnquobahrieMichelle A Williams

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