Maternal Plasma per- and Polyfluoroalkyl Substance Concentrations in Early Pregnancy and Maternal and Neonatal Thyroid Function in a Prospective Birth Cohort: Project Viva (USA)

Environmental Health Perspectives
Emma V PrestonSharon K Sagiv

Abstract

Prenatal exposure to some per- and polyfluoroalkyl substances (PFASs) may disrupt maternal and neonatal thyroid function, which is critical for normal growth and neurodevelopment. We examined associations of PFAS exposure during early pregnancy with maternal and neonatal thyroid hormone levels. We studied 732 mothers and 480 neonates in Project Viva, a longitudinal prebirth cohort in Boston, Massachusetts. We quantified six PFASs, including perfluorooctanoic acid (PFOA) and perfluorooctane sulfonate (PFOS), and maternal thyroid hormones [thyroxine (T4), Free T4 Index (FT4I), thyroid stimulating hormone (TSH)] in plasma samples collected at a median 9.6 wk gestation and neonatal T4 levels from postpartum heel sticks. We estimated associations of PFAS concentrations with thyroid hormone levels using covariate-adjusted linear regression models and explored effect measure modification by maternal thyroid peroxidase antibody (TPOAb) status and infant sex. PFAS concentrations were not associated with maternal T4, but PFOA, perfluorohexane sulfonate (PFHxS), and 2-(N-methyl-perfluorooctane sulfonamido) acetate (MeFOSAA) were inversely associated with maternal FT4I [e.g., -1.87% (95% confidence interval (CI): -3.40, -0.31) per interqua...Continue Reading

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Citations

Jun 5, 2020·Environmental Health : a Global Access Science Source·Xiaona HuoUNKNOWN Shanghai Birth Cohort
Nov 28, 2020·Environmental Health : a Global Access Science Source·Hong LiangWei Yuan
Oct 15, 2020·Environmental Health : a Global Access Science Source·Sophie A H BoesenEva C Bonefeld-Jørgensen
Feb 6, 2021·Frontiers in Endocrinology·Francesca CoperchiniLuca Chiovato
May 24, 2021·Environmental Health : a Global Access Science Source·Rahel L BirruJennifer J Adibi
Jul 28, 2021·Environmental Science & Technology·Blanca SarzoMaria-Jose Lopez-Espinosa

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Methods Mentioned

BETA
blood draw

Software Mentioned

SAS
R
R Foundation for Computing

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