Maternal prenatal psychological distress and hair cortisol levels associate with infant fecal microbiota composition at 2.5 months of age.

Psychoneuroendocrinology
Anna-Katariina AatsinkiLinnea Karlsson

Abstract

Maternal prenatal stress associates with infant developmental outcomes, but the mechanisms underlying this association are not fully understood. Alterations in the composition and function of infant intestinal microbiota may mediate some of the observed health effects, a viewpoint that is supported by animal studies along with a small human study showing that exposure to prenatal stress modifies the offspring's intestinal microbiota. In the current study, we aim to investigate the associations between maternal prenatal psychological distress (PPD) and hair cortisol concentration (HCC) with infant fecal microbiota composition in a large prospective human cohort. The study population was drawn from FinnBrain Birth Cohort Study. Maternal PPD was measured with standardized questionnaires (EPDS, SCL, PRAQ-R2, Daily Hassles) three times during pregnancy (n = 398). A measure addressing the chronicity of PPD was composed separately for each questionnaire. HCC was measured from a five cm segment at gestational week 24 (n = 115), thus covering the early and mid-pregnancy. Infant fecal samples were collected at the age of 2.5 months and analyzed with 16S rRNA amplicon sequencing. Maternal chronic PPD (all symptom measures) showed positive...Continue Reading

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Citations

Oct 21, 2020·Psychoneuroendocrinology·Kristine MarceauElizabeth A Shirtcliff
Jul 20, 2021·Behavioural Brain Research·Liisa Hantsoo, Babette S Zemel
Oct 19, 2021·Molecular Ecology·Kirsty J MacLeodTracy Langkilde
Nov 23, 2021·Frontiers in Immunology·Yue SunHailong Cao

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