Maternal prepregnancy body mass index and risk of neural tube defects: A population-based case-control study in Shanxi province, China

Birth Defects Research. Part A, Clinical and Molecular Teratology
Zhiwen LiAiguo Ren

Abstract

Many studies from the Western world have indicated that maternal obesity is associated with an increased risk of neural tube defects (NTDs). However, few reports have been available on this association from Asian populations. Our aim was to examine the relationship between maternal prepregnancy body mass index (BMI) and the risk of NTDs in a population of northern China. Data were derived from an ongoing population-based case-control study of birth defects in Shanxi province, China. Subjects were 511 NTD cases and 687 controls selected from the same population between January 2003 and June 2007. BMI was based on maternal height and prepregnancy weight as reported within 1 week of delivery. We found no significantly increased risk of NTDs for obese women (adjusted odds ratio [OR], 0.65; 95% confidence interval [CI], 0.29-1.49) or for underweight women (adjusted OR, 1.00; 95% CI, 0.62-1.62) relative to normal-weight women. We found a significantly reduced risk of overall NTDs (adjusted OR, 0.56; 95% CI, 0.41-0.76) and anencephaly (adjusted OR, 0.40; 95% CI, 0.26-0.62) for overweight women compared to normal-weight women. Our results do not support the association between maternal prepregnancy obesity and increased risk of overall...Continue Reading

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Citations

May 9, 2016·Obesity Research & Clinical Practice·Hai-Yan HuangLi-Ping Feng
Apr 23, 2019·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Le ZhangRongwei Ye

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