Maternal prepregnancy obesity and achievement of infant motor developmental milestones in the upstate KIDS study

Obesity
Amanda WylieEdwina H Yeung

Abstract

Maternal prepregnancy obesity is associated with several poor infant health outcomes; however, studies that investigated motor development have been inconsistent. Thus, maternal prepregnancy weight status and infants' gross motor development were examined. Participants consisted of 4,901 mother-infant pairs from the Upstate KIDS study, a longitudinal cohort in New York. Mothers indicated dates when infants achieved each of six gross motor milestones when infants were 4, 8, 12, 18, and 24 months old. Failure time modeling under a Weibull distribution was utilized to compare time to achievement across three levels of maternal prepregnancy BMI. Hazard ratios (HR) below one indicate a lower "risk" of achieving the milestone and translate to later achievement. Compared to infants born to thin and normal-weight mothers (BMI < 25), infants born to mothers with obesity (BMI > 30) were slower to sit without support (HR = 0.91, P = 0.03) and crawl on hands and knees (HR = 0.86, P < 0.001), after adjusting for maternal and birth characteristics. Increased gestational age was associated with faster achievement of all milestones, but additional adjustment did not impact results. Maternal prepregnancy obesity was associated with a slightly l...Continue Reading

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Citations

Oct 28, 2015·Developmental Medicine and Child Neurology·Akhgar GhassabianEdwina Yeung
Aug 17, 2016·International Journal of Obesity : Journal of the International Association for the Study of Obesity·A A AdaneL R Tooth
Sep 6, 2019·Journal of Developmental Origins of Health and Disease·Amy R NicholsElizabeth M Widen
Mar 20, 2019·European Child & Adolescent Psychiatry·Alexa GrudzinskiStefan Kuhle
Apr 25, 2018·International Journal of Obesity : Journal of the International Association for the Study of Obesity·Polina GirchenkoKatri Räikkönen
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Jan 4, 2017·Pediatrics·Edwina H YeungGermaine Buck Louis

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