Maternal protein intake in the pregnant rat programs the insulin axis and body composition in the offspring

Metabolism: Clinical and Experimental
William D ReesGeorge Grant

Abstract

Evidence to support an association between early nutrition and the development of obesity in the rat is equivocal. In this study we have investigated the postnatal growth, glucose tolerance, and adipocyte function of the offspring from pregnant rats fed with diets containing either 20% or 8% protein during gestation. By 25 weeks of age, the female offspring of dams fed with the diet containing 8% protein had a significantly lower adult body weight due in part to a decrease in body fat. The peak concentration of insulin after oral administration of a glucose dose was significantly lower in both the male and female offspring of the dams fed with the diet containing 8% protein. However, the ability of insulin to stimulate lipogenesis or suppress lipolysis in fat cells isolated from the offspring was not influenced by the prenatal diet. Hepatic phosphoenolpyruvate carboxykinase activity was reduced in female offspring of dams fed with the diet containing 8% protein. These results show that adult body composition is determined during the prenatal period as a result of programming of the insulin axis. This metabolic programming influences hepatic metabolism; however, there is no evidence for a programmed change in adipocyte function.

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Citations

Dec 19, 2008·Pediatric Research·Sarah E ToddJane E Harding
Sep 4, 2013·Pflügers Archiv : European journal of physiology·Jean-Louis GuéantRosa-Maria Guéant-Rodriguez
Jan 4, 2007·Seminars in Fetal & Neonatal Medicine·Liza H Kunz, Janet C King
Apr 21, 2007·Journal of Internal Medicine·M S Martin-Gronert, S E Ozanne
Aug 5, 2006·Early Human Development·Hans DemmelmairBerthold Koletzko
May 23, 2006·Metabolism: Clinical and Experimental·William D ReesMorven Cruickshank
Feb 19, 2008·American Journal of Obstetrics and Gynecology·Bianca Martins GregórioMárcia Barbosa Aguila
Oct 11, 2012·European Journal of Clinical Nutrition·J YinG Jones
Apr 17, 2007·The British Journal of Nutrition·Christopher A MaloneyWilliam D Rees
Jan 15, 2009·American Journal of Physiology. Endocrinology and Metabolism·Fiona A WilsonGerald E Lobley
Nov 6, 2010·Endocrine Reviews·Floor Remmers, Henriette A Delemarre-van de Waal
Oct 18, 2007·Current Opinion in Endocrinology, Diabetes, and Obesity

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