Maternal PUFA status and offspring allergic diseases up to the age of 18 months

The British Journal of Nutrition
Ya-Mei YuGUSTO Study Group

Abstract

Studies have suggested that maternal PUFA status during pregnancy may influence early childhood allergic diseases, although findings are inconsistent. We examined the relationship between maternal PUFA status and risk of allergic diseases in early childhood in an Asian cohort. Maternal plasma samples from the Growing Up in Singapore Towards Healthy Outcomes mother-offspring cohort were assayed at 26-28 weeks of gestation for relative abundance of PUFA. Offspring (n 960) were followed up from 3 weeks to 18 months of age, and clinical outcomes of potential allergic diseases (rhinitis, eczema and wheezing) were assessed by repeated questionnaires. Skin prick testing (SPT) was also performed at the age of 18 months. Any allergic disease with positive SPT was defined as having any one of the clinical outcomes plus a positive SPT. The prevalence of a positive SPT, rhinitis, eczema, wheezing and any allergic disease with positive SPT was 14·1 % (103/728), 26·5 % (214/808), 17·6 % (147/833), 10·9 % (94/859) and 9·4 % (62/657), respectively. After adjustment for confounders, maternal total n-3, n-6 PUFA status and the n-6:n-3 PUFA ratio were not significantly associated with offspring rhinitis, eczema, wheezing, a positive SPT and havin...Continue Reading

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Citations

Apr 5, 2016·European Journal of Pharmacology·Linette E M Willemsen
Apr 8, 2016·Current Opinion in Allergy and Clinical Immunology·Caroline J Lodge, Shyamali C Dharmage
Mar 12, 2020·Clinical Reviews in Allergy & Immunology·Chun-Min KangLi-Chieh Wang
Oct 19, 2019·The Journal of Allergy and Clinical Immunology. in Practice·Kourtney G GardnerKecia N Carroll

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