Maternal regulation of the infant's hypothalamic-pituitary-adrenal axis stress response: Seymour 'Gig' Levine's legacy to neuroendocrinology

Journal of Neuroendocrinology
Deborah Suchecki

Abstract

Thirty years ago, Seymour 'Gig' Levine published a serendipitous, yet, seminal finding with respect to the regulatory role of maternal presence on the corticosterone stress response of neonatal rats during the developmental period known as the stress hyporesponsive period. At the same time, his group of students also investigated the stress response of infant monkeys with respect to maternal separation, as a means of understanding the stress to the primary caregiver resulting from disruptions of attachment. Gig and his group of students and collaborators, mainly in the USA and the Netherlands, investigated how initial social relationships buffer the stress response of nonhuman primates and rodent infants. His work in rodents involved determining how prolonged deprivation of maternal care disinhibits the stress response of neonates and how maternal behaviours regulate specific aspects of the hypothalamic-pituitary-adrenal axis. Maternal deprivation for 24 hours was useful for determining the importance of nutrition in suppressing the corticosterone stress response, whereas anogenital licking and grooming inhibited stress-induced adrenocortoctrophic hormone release, with the combination of both behaviours preventing the effects o...Continue Reading

References

Dec 1, 1979·Physiology & Behavior·M B HennessyS Levine
Mar 1, 1978·Developmental Psychobiology·S P MendozaS Levine
Jan 1, 1978·Physiology & Behavior·S LevineW P Smotherman
Jan 1, 1979·The Journal of Pediatrics·R A BallardS Sniderman
Jul 16, 1991·Brain Research. Developmental Brain Research·J A van EekelenE R de Kloet
Oct 1, 1991·Physiology & Behavior·P RosenfeldS Levine
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Jan 1, 1988·Annual Review of Physiology·E R Simpson, M R Waterman
Jul 1, 1988·Brain Research·P RosenfeldE R De Kloet
Mar 1, 1987·Developmental Psychobiology·M E StantonS Levine
Jul 1, 1965·Proceedings of the National Academy of Sciences of the United States of America·H F HarlowM K Harlow
Aug 1, 1980·Neuroendocrinology·N M SchoenfeldJ Rabii
Sep 16, 1980·Biochemical and Biophysical Research Communications·P Durand, A Locatelli
Jan 1, 1981·Psychoneuroendocrinology·M R GunnarJ M Donhowe
Jun 1, 1994·Acta Paediatrica. Supplement·L A Rosenblum, M W Andrews
Oct 15, 1993·Brain Research. Developmental Brain Research·D SucheckiS Levine
Jul 1, 1993·Developmental Psychobiology·P RosenfeldS Levine
Jan 1, 1997·Neuroscience and Biobehavioral Reviews·M B Hennessy
May 1, 1997·Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie·R C Bland
Jan 14, 1998·Brain Research. Developmental Brain Research·J O WorkelE R De Kloet
Jun 6, 1998·Proceedings of the National Academy of Sciences of the United States of America·C CaldjiM J Meaney

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Citations

Mar 6, 2019·Global Advances in Health and Medicine : Improving Healthcare Outcomes Worldwide·Christina L Ross
Dec 21, 2020·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Kristina CsatlosovaEliyahu Dremencov
Sep 27, 2020·Journal of Affective Disorders·Dan-Dan ZhangYing Sun
Apr 20, 2021·The European Journal of Neuroscience·Maša Čater, Gregor Majdič
Aug 24, 2021·Developmental Psychobiology·Natália C ZantaCarlos Eduardo Neves Girardi

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