Maternal report of fever from cold or flu during early pregnancy and the risk for noncardiac birth defects, National Birth Defects Prevention Study, 1997-2011

Birth Defects Research
Dorothy Kim WallerNational Birth Defects Prevention Study

Abstract

As maternal fever affects approximately 6-8% of early pregnancies, it is important to expand upon previous observations of an association between maternal fever and birth defects. We analyzed data from the National Birth Defects Prevention Study, a multistate, case-control study of major structural birth defects. Telephone interviews were completed by mothers of cases (n = 17,162) and controls (n = 10,127). Using multivariable logistic regression, we assessed the association between maternal self-report of cold or flu with fever and cold or flu without fever during early pregnancy and 30 categories of non-cardiac birth defects. Maternal report of cold or flu with fever was significantly associated with 8 birth defects (anencephaly, spina bifida, encephalocele, cleft lip with or without cleft palate, colonic atresia/stenosis, bilateral renal agenesis/hypoplasia, limb reduction defects, and gastroschisis) with elevated adjusted odds ratios ranging from 1.2 to 3.7. Maternal report of cold or flu without fever was not associated with any of the birth defects studied. This study adds to the evidence that maternal fever during early pregnancy is associated with an increased risk for selected birth defects. Elevated associations were ...Continue Reading

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Citations

Jun 5, 2018·Epidemiology·Martha M WerlerSamantha E Parker
Jul 23, 2019·Birth Defects Research·Mary M JenkinsUNKNOWN National Birth Defects Prevention Study
Jan 12, 2020·Birth Defects Research·Santiago CerrizuelaManuel J Aybar
Jul 21, 2020·Birth Defects Research·John M Graham
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Mar 12, 2021·Curēus·Roohi Afshan Kaleelullah, Neha Garugula
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Dec 18, 2021·The Cleft Palate-craniofacial Journal : Official Publication of the American Cleft Palate-Craniofacial Association·Fang-Ping ShiSi-Yuan Liang

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Birth defects encompass structural and functional alterations that occur during embryonic or fetal development and are present since birth. The cause may be genetic, environmental or unknown and can result in physical and/or mental impairment. Here is the latest research on birth defects.

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