Maternal reports of family history from the National Birth Defects Prevention Study, 1997-2001

Genetics in Medicine : Official Journal of the American College of Medical Genetics
Ridgely Fisk GreenNational Birth Defects Prevention Study

Abstract

To assess usefulness of family history information obtained in pediatric practice, we evaluated maternally reported family history data. We analyzed family history responses from the National Birth Defects Prevention Study using interview data from mothers of children with birth defects (n = 9,331) and of unaffected liveborn children (n = 3,390) with 1997-2001 estimated delivery dates. We examined the effects of demographic factors, case-control status, and type of defect on birth defect family history reports. Interview information was compared with occurrence of prenatal testing. Among case mothers, 1,577 (17%) reported a first- or second-degree relative with a birth defect, compared with 327 (10%) control mothers (odds ratio = 1.91, 95% confidence interval = 1.68-2.16). Reports of affected relatives were also more frequent among mothers who were non-Hispanic white, were 25 years or older, had more than 12 years of education, had an annual household income greater than $20,000, were born in the United States, and completed an English-language interview. Reporting a family history of birth defects might be influenced by maternal demographic factors, which should be considered in developing pediatric family history tools.

References

Mar 13, 2002·Public Health Reports·P W YoonL D Edmonds
Aug 13, 2002·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Paula W YoonMuin J Khoury
Feb 6, 2003·American Journal of Preventive Medicine·Paula W YoonMuin J Khoury
May 15, 2003·American Journal of Preventive Medicine·Sandra D LaneLloyd F Novick
Jan 6, 2004·Birth Defects Research. Part A, Clinical and Molecular Teratology·Adolfo Correa-VillaseñorLaura Williams
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Nov 27, 2004·The New England Journal of Medicine·Alan E GuttmacherRichard H Carmona

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Citations

Mar 6, 2021·The American Journal of Clinical Nutrition·Julie M PetersenUNKNOWN National Birth Defects Prevention Study

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Birth defects encompass structural and functional alterations that occur during embryonic or fetal development and are present since birth. The cause may be genetic, environmental or unknown and can result in physical and/or mental impairment. Here is the latest research on birth defects.

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