Maternal residential proximity to major roadways at delivery and childhood central nervous system tumors

Environmental Research
Heather E DanyshPhilip J Lupo

Abstract

Due to concerns over the impact of traffic-related air pollution on childhood cancers, we evaluated the association between residential proximity to major roadways and childhood central nervous system (CNS) tumors. The Texas Cancer Registry provided information on children diagnosed with a CNS tumor at <5 years of age and born in Texas for the period 2003-2009 (n=315). Birth certificate controls were frequency matched to cases (5:1) on birth year (n=1575). We assigned exposures to traffic-related air pollution using residential proximity to major roadways based on the maternal residence at the time of delivery. Logistic regression was used to generate unadjusted and adjusted odds ratios and 95% confidence intervals (CI). We evaluated CNS tumors as a group and by histologic type. Maternal residential proximity to major roadways at delivery was positively associated with the odds of offspring having a CNS tumor. Specifically, for every kilometer closer to a major roadway, the odds of offspring having a CNS tumor increased by 30% (95% CI: 1.0, 1.7). Mothers living ≤500 meters (m) from a major roadway were 31% (95% CI: 1.0, 1.8) more likely to have offspring with any CNS tumor and 3.1-times (95% CI: 0.9, 10.4) more likely to have o...Continue Reading

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Citations

Mar 8, 2016·Environmental Research·Javier García-PérezRebeca Ramis
Mar 14, 2018·International Journal of Environmental Research and Public Health·Shwetha V KumarHeather E Danysh
Jun 12, 2019·International Journal of Environmental Research and Public Health·Erin C Peckham-GregoryPhilip J Lupo
Jan 18, 2018·International Journal of Molecular Sciences·Tianliang ZhangLi Yu

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