Maternal second trimester blood levels of selected heavy metals in pregnancies complicated with neural tube defects

The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
Şule ÖzelYaprak Engin-Ustun

Abstract

Neural tube defects (NTDs) are the most common malformations of the central nervous system (CNS). There is continuing research for the identification of risk factors and interventions for prevention of NTDs. The aim of this study was to investigate the maternal second trimester blood levels of selected heavy metals namely, arsenic (As), cadmium (Cd), mercury (Hg), manganese (Mn), nickel (Ni), and lead (Pb) and their possible relation with the occurrence of NTDs. Twenty-one healthy second trimester pregnant women with fetuses affected with NTD (cases) were matched with 21 healthy pregnant women with unaffected fetuses (controls) with respect to age, body mass index (BMI), and gestational age. Maternal blood levels of heavy metals were measured after an overnight fasting period. No significant differences were observed in terms of maternal blood levels of As, Cd, Hg, and Ni between NTD-affected and unaffected pregnancies. The blood Pb and Mn levels were found to be higher in pregnant women with a fetus affected with NTD when compared with pregnant women with unaffected fetuses (for Pb, in cases 12.3 ± 5.5 µg/L, in controls 7.8 ± 2.4 µg/L; for Mn in cases 3.6 ± 1.4 µg/L, in controls 2.4 ± 1.0 µg/L, p < .05). High maternal second t...Continue Reading

References

Oct 1, 1974·Teratology·A R Beaudoin
Aug 26, 1998·Reproductive Toxicology·J M DeSessoJ F Holson
Oct 27, 1998·American Journal of Industrial Medicine·A IrgensL M Irgens
Jan 28, 2004·Birth Defects Research. Part B, Developmental and Reproductive Toxicology·Andriana D PapaconstantinouPeter L Goering
Jun 29, 2004·Reproductive Toxicology·Estíbaliz L FernandezAnne-Lee Gustafson
Oct 27, 2004·Reproductive Toxicology·María de Lourdes Carrillo-PonceFrancisca Sanmiguel
Sep 21, 2005·Environmental Research·Jean D BrenderKatherine Hendricks
Sep 27, 2005·Reproductive Toxicology·Jennifer ThompsonJohn Bannigan
Nov 26, 2005·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Jose G Dorea, Carmen M Donangelo
Aug 8, 2006·Neurotoxicology·Steven G Gilbert, Bernard Weiss
Oct 10, 2007·Journal of Pediatric Surgery·Jennifer M Thompson, John G Bannigan
Jan 11, 2008·Birth Defects Research. Part B, Developmental and Reproductive Toxicology·Denise S HillRichard H Finnell
Feb 5, 2008·Reproductive Toxicology·Mohsen VigehShunichi Araki
Mar 18, 2008·Aquatic Toxicology·Elly Suk Hen ChowShuk Han Cheng
Mar 18, 2009·Epidemiology·Ami R ZotaRobert O Wright
Jul 2, 2009·Nutrition Reviews·Richard J Wood
Aug 4, 2009·Lancet·Helen Dolk, UNKNOWN EUROCAT Project Management Committee
Sep 26, 2009·Seminars in Pediatric Neurology·Alexander G Bassuk, Zoha Kibar
Mar 11, 2010·Current Opinion in Pediatrics·Donald R Mattison
Mar 23, 2011·Birth Defects Research. Part C, Embryo Today : Reviews·Heather J Hamlin, Louis J Guillette
Jun 11, 2011·Toxicological Sciences : an Official Journal of the Society of Toxicology·Annalisa PinsinoValeria Matranga
Jul 5, 2011·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Zhong-Ji HanXu Ma
Nov 3, 2012·Interdisciplinary Toxicology·Gagan FloraArchana Tiwari
May 15, 2013·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Jufen LiuAiguo Ren
Jan 31, 2014·Environmental Science and Pollution Research International·Limei ChenYing Tian
Feb 19, 2014·Current Opinion in Pediatrics·Birgit Claus HennRobert O Wright
Feb 19, 2014·Birth Defects Research. Part A, Clinical and Molecular Teratology·Anne M MolloyJames L Mills
Apr 18, 2015·Environmental Health : a Global Access Science Source·Maitreyi MazumdarDavid C Christiani
Nov 17, 2015·Journal of Toxicology and Environmental Health. Part a·Suzanne McDermottJamie Lead
Jun 22, 2016·Birth Defects Research·Nicholas D E GreeneAndrew J Copp
Dec 5, 2017·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Nihat DemirOğuz Tuncer

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
Nihat DemirOğuz Tuncer
European Journal of Gastroenterology & Hepatology
Rodrigo Coutinho de AlmeidaRiccardo Pratesi
© 2022 Meta ULC. All rights reserved