Maternal separation and handling affects cocaine self-administration in both the treated pups as adults and the dams

The Journal of Pharmacology and Experimental Therapeutics
M C MoffettM J Kuhar

Abstract

Repeated maternal separation of pups from dams is often used as an early life stressor that causes profound neurochemical and behavioral changes in the pups that persist into adulthood. The effects of maternal separation on both the dams and the treated pups as adults on cocaine self-administration were examined using four separation conditions: 15- or 180-min separation (MS15 and MS180), brief handling without separation (MS0), and a nonhandled group (NH). The separations and handling occurred daily on postnatal days 2 to 15. The acquisition of cocaine self-administration (0.0625-1.0 mg/kg/infusion) was evaluated in the treated pups as adults. The MS180 group acquired cocaine self-administration at the lowest dose tested (0.0625 mg/kg/infusion), whereas the MS15s did not respond for cocaine at rates greater than that seen with saline administration. The NH group received the greatest number of infusions and intake at the highest doses. After self-administration, no differences were observed between groups in activity of two liver carboxylesterases involved in the inactivation of cocaine, ES10 and ES4. Maternal separation affected cocaine self-administration in the dams as well. Although there was an overall significant affect ...Continue Reading

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Citations

Nov 23, 2010·Psychopharmacology·Ana-João RodriguesNuno Sousa
May 7, 2010·Behavioural Pharmacology·Stephen J Kohut, Anthony L Riley
Jan 28, 2014·Psychopharmacology·Jessica J Stanis, Susan L Andersen
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Jul 1, 2008·Neuroscience and Biobehavioral Reviews·Roberto CoccurelloAnna Moles
Dec 22, 2006·Progress in Neuro-psychopharmacology & Biological Psychiatry·Peter G RomaAnthony L Riley
Jun 10, 2009·Developmental Psychobiology·Georgios KiosterakisFotini Stylianopoulou
Sep 12, 2006·Biochemical Pharmacology·M C MoffettM J Kuhar
Dec 24, 2014·Behavioural Brain Research·Emily Hensleigh, Laurel M Pritchard
Dec 3, 2014·Neuroscience and Biobehavioral Reviews·Elizabeth J CroftonThomas A Green
May 22, 2010·Behavioural Brain Research·Vanessa MourlonValérie Daugé
Apr 8, 2017·Neuroscience and Biobehavioral Reviews·Virginie Rappeneau, Anne Bérod
Apr 25, 2017·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Michael J LacagninaStaci D Bilbo
Jan 22, 2008·The Journal of Pharmacology and Experimental Therapeutics·Clifford C Michaels, Stephen G Holtzman
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Jun 27, 2019·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Jared R BagleyTod E Kippin
Apr 8, 2021·The European Journal of Neuroscience·Sophia C LevisStephen V Mahler

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